TOR Signaling Is Going through a Phase

被引：5

作者：

Prouteau, Manoel ^{[1
,2
]}

Loewith, Robbie ^{[1
,2
,3
]}

机构：

[1] Univ Geneva, Dept Mol Biol, 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland

[2] Univ Geneva, Med Sch CMU, Inst Genet & Genom Geneva iGE3, 1 Rue Michel Servet, CH-1211 Geneva 4, Switzerland

[3] Univ Geneva, Swiss Natl Ctr Competence Res NCCR Chem Biol, Sci 2, Room 3-308,30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland

来源：

CELL METABOLISM | 2019年 / 29卷 / 05期

基金：

欧洲研究理事会; 瑞士国家科学基金会;

关键词：

D O I：

10.1016/j.cmet.2019.04.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recently in Cell, Kato et al. (2019) and Yang et al. (2019) report that reversible oxidation of multiple methionines in a region of Pbp1, the yeast paralog of ataxin-2 protein, couples metabolic redox status to phase separation of Pbp1 into liquid-like condensates. In turn, Pbp1 condensates inhibit target of rapamycin complex 1 (TORC1) signaling and thereby induce autophagy and restore metabolic homeostasis.

引用

页码：1019 / 1021

页数：4

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