TOR Signaling Is Going through a Phase

被引：5
|
作者：
Prouteau, Manoel [1 ,2 ]
Loewith, Robbie [1 ,2 ,3 ]
机构：
[1] Univ Geneva, Dept Mol Biol, 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland
[2] Univ Geneva, Med Sch CMU, Inst Genet & Genom Geneva iGE3, 1 Rue Michel Servet, CH-1211 Geneva 4, Switzerland
[3] Univ Geneva, Swiss Natl Ctr Competence Res NCCR Chem Biol, Sci 2, Room 3-308,30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland
来源：
CELL METABOLISM | 2019年 / 29卷 / 05期
基金：
欧洲研究理事会; 瑞士国家科学基金会;
关键词：
D O I：
10.1016/j.cmet.2019.04.010
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Recently in Cell, Kato et al. (2019) and Yang et al. (2019) report that reversible oxidation of multiple methionines in a region of Pbp1, the yeast paralog of ataxin-2 protein, couples metabolic redox status to phase separation of Pbp1 into liquid-like condensates. In turn, Pbp1 condensates inhibit target of rapamycin complex 1 (TORC1) signaling and thereby induce autophagy and restore metabolic homeostasis.
引用
收藏
页码：1019 / 1021
页数：4
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