Stereoselective synthesis of (+)-CP-99,994: A substance P non-peptide antagonist.

被引：40
|
作者：
Chandrasekhar, S [1 ]
Mohanty, PK [1 ]
机构：
[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 27期
关键词：
stereoselective; nonchelation control; one-pot reactions; piperidine; (+)-CP-99,994;
D O I：
10.1016/S0040-4039(99)00983-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly stereoflexible total synthesis of(+)-CP-99,994 is achieved starting, from (S)-serine. key steps being a diastereoselective Grignard addition, a one-pot reductive protection of an azide, and one-pot oxidative Wittig olefination. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：5071 / 5072
页数：2
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