Alternative strategies for the stereoselective synthesis of enantioenriched 6-arylated piperidin-2-ones

被引：11

作者：

Sallio, Romain ^{[1
,2
]}

Lebrun, Stephane ^{[1
,2
]}

Agbossou-Niedercorn, Francine ^{[1
,3
,4
]}

Michon, Christophe ^{[1
,3
,4
]}

Deniau, Eric ^{[1
,2
]}

机构：

[1] Univ Lille Nord France, F-59000 Lille, France

[2] Univ Lille 1, EA CMF 4478, Chim Organ Phys Lab, F-59655 Villeneuve Dascq, France

[3] UCCS, CNRS, UMR 8181, F-59655 Villeneuve Dascq, France

[4] ENSCL, CCM CCCF, F-59652 Villeneuve Dascq, France

来源：

TETRAHEDRON-ASYMMETRY | 2012年 / 23卷 / 13期

关键词：

HIGHLY ENANTIOSELECTIVE HYDROGENATION; ASYMMETRIC-SYNTHESIS; CATALYZED HYDROGENATION; SUZUKI-MIYAURA; PHOSPHATES; ALKALOIDS; CYCLOADDITION; COMPLEX; BOND; N; N-DIALKYLHYDRAZONES;

D O I：

10.1016/j.tetasy.2012.06.024

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two alternative synthetic approaches to a variety of enantioenriched 6-arylated piperidin-2-ones have been developed. The first one is based on the hydrogenation of suitably arylated chiral cyclic enehydrazides. The second approach relies on the asymmetric catalytic hydrogenation of the corresponding N-alkylated precursors. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：998 / 1004

页数：7

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