Par-4 prevents breast cancer recurrence

被引：2

作者：

Hebbar, Nikhil ^{[1
]}

Shrestha-Bhattarai, Tripti ^{[1
]}

Rangnekar, Vivek M. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Kentucky, Grad Ctr Toxicol, Lexington, KY 40536 USA

[2] Univ Kentucky, Dept Radiat Med, Lexington, KY 40536 USA

[3] Univ Kentucky, Dept Microbiol Immunol, Lexington, KY 40536 USA

[4] Univ Kentucky, Dept Mol Genet, Lexington, KY 40536 USA

[5] Univ Kentucky, LP Markey Canc Ctr, Lexington, KY USA

来源：

BREAST CANCER RESEARCH | 2013年 / 15卷 / 05期

基金：

美国国家卫生研究院;

关键词：

DOWN-REGULATION; APOPTOSIS; GENE;

D O I：

10.1186/bcr3562

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Therapy resistance and disease recurrence are two of the most challenging aspects in breast cancer treatment. A recent article in Cancer Cell makes a significant contribution toward a better understanding of this therapeutic problem by establishing downregulation of the tumor suppressor Par-4 as the primary determinant of breast cancer recurrence. This viewpoint brings forth the importance of their findings and its implications on future research and therapy.

引用

页数：2

共 50 条

[21] PAR-4 as a possible new target for pancreatic cancer therapy
Azmi, Asfar S.
Philip, Philip A.
Zafar, Syed F.
Sarkar, Fazlul H.
Mohammad, Ramzi M.
EXPERT OPINION ON THERAPEUTIC TARGETS, 2010, 14 (06) : 611 - 620
[22] Cancer-Selective Apoptosis by Tumor Suppressor Par-4
Hebbar, Nikhil
Shrestha-Bhattarai, Tripti
Rangnekar, Vivek M.
ANTICANCER GENES, 2014, 818 : 155 - 166
[23] PAR-4 overcomes chemo-resistance in breast cancer cells by antagonizing cIAP1
Haihong Guo
Fabian Treude
Oliver H. Krämer
Bernhard Lüscher
Jörg Hartkamp
Scientific Reports, 9
[24] PAR-4 overcomes chemo-resistance in breast cancer cells by antagonizing cIAP1
Guo, Haihong
Treude, Fabian
Kraemer, Oliver H.
Luescher, Bernhard
Hartkamp, Jorg
SCIENTIFIC REPORTS, 2019, 9 (1)
[25] Regulation of Par-4 by oncogenic Ras
Vasudevan, Krishna Murthi
Ranganathan, Padhma
Rangnekar, Vivek M.
REGULATORS AND EFFECTORS OF SMALL GTPASES: RAS FAMILY, 2006, 407 : 422 - 442
[26] Breast-cancer vaccine prevents recurrence
Brower, Vicki
LANCET ONCOLOGY, 2008, 9 (03): : 208 - 208
[27] Immunohistochemical Analysis of Prostate Apoptosis Response-4 (Par-4) in Mexican Women with Breast Cancer: A Preliminary Study
Fernando Mendez-Lopez, Luis
Zapata-Benavides, Pablo
Zavala-Pompa, Angel
Elias Aguado-Barrera, Miguel
Pacheco-Calleros, Javier
Rodriguez-Padilla, Cristina
Martin Cerda-Flores, Ricardo
Irene Cortes-Gutierrez, Elva
Imelda Davila-Rodriguez, Martha
ARCHIVES OF MEDICAL RESEARCH, 2010, 41 (04) : 261 - 268
[28] Down-regulation of the candidate tumor suppressor gene PAR-4 is associated with poor prognosis in breast cancer
Nagai, Maria Aparecida
Gerhard, Rene
Salaorni, Sibeli
Tavares Guerreiro Fregnani, Jose Humberto
Nonogaki, Suely
Netto, Mario Mourao
Soares, Fernando Augusto
INTERNATIONAL JOURNAL OF ONCOLOGY, 2010, 37 (01) : 41 - 49
[29] Novel Mechanism of Apoptosis Resistance in Cancer Mediated by Extracellular PAR-4
Burikhanov, Ravshan
Shrestha-Bhattarai, Tripti
Qiu, Shirley
Shukla, Nidhi
Hebbar, Nikhil
Lele, Subodh M.
Horbinski, Craig
Rangnekar, Vivek M.
CANCER RESEARCH, 2013, 73 (02) : 1011 - 1019
[30] Cancer-selective apoptotic effects of extracellular and intracellular Par-4
Shrestha-Bhattarai, T.
Rangnekar, V. M.
ONCOGENE, 2010, 29 (27) : 3873 - 3880

← 1 2 3 4 5 →