Targeting Myc in triple negative breast cancer models through the dual inhibition of PIM kinases and CDK9

被引:0
|
作者
Haws, Hillary [1 ]
Kim, Wontak [1 ]
Siddiqui-Jain, Adam [1 ]
Bearss, David J. [1 ]
Warner, Steven L. [1 ]
Whatcott, Clifford J. [1 ]
机构
[1] Tolero Pharmaceut Inc, Lehi, UT USA
关键词
D O I
10.1158/1535-7163.TARG-17-B178
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
B178
引用
收藏
页数:2
相关论文
共 50 条
  • [31] MicroRNA-874 inhibits cell proliferation and induces apoptosis in human breast cancer by targeting CDK9
    Wang, Ling
    Gao, Wen
    Hu, Fan
    Xu, Zhiyang
    Wang, Fuqiang
    FEBS LETTERS, 2014, 588 (24) : 4527 - 4535
  • [32] Nanobiopolymer for Direct Targeting and Inhibition of EGFR Expression in Triple Negative Breast Cancer
    Inoue, Satoshi
    Patil, Rameshwar
    Portilla-Arias, Jose
    Ding, Hui
    Konda, Bindu
    Espinoza, Andres
    Mongayt, Dmitriy
    Markman, Janet L.
    Elramsisy, Adam
    Phillips, H. Westley
    Black, Keith L.
    Holler, Eggehard
    Ljubimova, Julia Y.
    PLOS ONE, 2012, 7 (02):
  • [33] Targeting Receptor Tyrosine Kinases as a Novel Strategy for the Treatment of Triple-Negative Breast Cancer
    Jaradat, Sara K.
    Ayoub, Nehad M.
    Al Sharie, Ahmed H.
    Aldaod, Julia M.
    TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2024, 23
  • [34] Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP
    Shen, Liangliang
    O'Shea, John M.
    Kaadige, Mohan R.
    Cunha, Stephanie
    Wilde, Blake R.
    Cohen, Adam L.
    Welm, Alana L.
    Ayer, Donald E.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (17) : 5425 - 5430
  • [35] Investigating CDK4/6 inhibition in triple-negative breast cancer.
    Guo, Qiuchen
    Goreczny, Gregory J.
    Maynard, Adam
    Spasic, Milos
    McAllister, Sandra S.
    CANCER IMMUNOLOGY RESEARCH, 2020, 8 (03) : 40 - 40
  • [36] MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer
    Yang, Aimin
    Qin, Shenghui
    Schulte, Bradley A.
    Ethier, Stephen P.
    Tew, Kenneth D.
    Wang, Gavin Y.
    CANCER RESEARCH, 2017, 77 (23) : 6641 - 6650
  • [37] PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression
    Dai Horiuchi
    Roman Camarda
    Alicia Y Zhou
    Christina Yau
    Olga Momcilovic
    Sanjeev Balakrishnan
    Alexandra N Corella
    Henok Eyob
    Kai Kessenbrock
    Devon A Lawson
    Lindsey A Marsh
    Brittany N Anderton
    Julia Rohrberg
    Ratika Kunder
    Alexey V Bazarov
    Paul Yaswen
    Michael T McManus
    Hope S Rugo
    Zena Werb
    Andrei Goga
    Nature Medicine, 2016, 22 : 1321 - 1329
  • [38] PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression
    Horiuchi, Dai
    Camarda, Roman
    Zhou, Alicia Y.
    Yau, Christina
    Momcilovic, Olga
    Balakrishnan, Sanjeev
    Corella, Alexandra N.
    Eyob, Henok
    Kessenbrock, Kai
    Lawson, Devon A.
    Marsh, Lindsey A.
    Anderton, Brittany N.
    Rohrberg, Julia
    Kunder, Ratika
    Bazarov, Alexey V.
    Yaswen, Paul
    McManus, Michael T.
    Rugo, Hope S.
    Werb, Zena
    Goga, Andrei
    NATURE MEDICINE, 2016, 22 (11) : 1321 - 1329
  • [39] Synergy of ZEN3694 and VIP152 for dual transcriptional targeting of BET and CDK9 in patient derived organoid models of pancreatic cancer
    Koeppel, Lucas J.
    Stram, Austin
    Millikin, Robert J.
    Riedl, Ellie
    Hossan, Md Shahadat
    Lin, Ethan Samuel
    Stewart, Ron
    Kratz, Jeremy D.
    CANCER RESEARCH, 2024, 84 (06)
  • [40] Enhancing radiosensitivity in triple-negative breast cancer through targeting ELOB
    Guo Li
    Xinyue Lin
    Xinpeng Wang
    Lvjuan Cai
    Jianren Liu
    Yunyun Zhu
    Zhichao Fu
    Breast Cancer, 2024, 31 : 426 - 439