The impact of maternal anti-retroviral therapy on cytokine profile in the uninfected neonates

被引：10
|
作者：
Kasahara, Taissa M. [1 ]
Hygino, Joana [1 ]
Blanco, Bernardo [1 ]
Xavier, Luciana [1 ]
Araujo-Lima, Carlos Fernando [1 ]
Guillermo, Landi V. C. [1 ]
Bittencourt, Vera Carolina B. [1 ]
Guimaraes, Vander [2 ]
Andrade, Arnaldo F. B. [3 ]
Bento, Cleonice A. M. [1 ]
机构：
[1] Univ Fed Rio de Janeiro, Dept Microbiol & Parasitol, BR-20261040 Rio De Janeiro, Brazil
[2] Inst Oswaldo Cruz, Fernandes Figueira Inst, BR-20001 Rio De Janeiro, Brazil
[3] Univ Estado Rio De Janeiro, Dept Microbiol Parasitol & Immunol, Rio De Janeiro, Brazil
来源：
HUMAN IMMUNOLOGY | 2013年 / 74卷 / 09期
关键词：
IMMUNODEFICIENCY-VIRUS TYPE-1; REGULATORY T-CELLS; IMMUNE-RESPONSES; NATURAL-KILLER; TRANSMISSION; PREGNANCY; RISK; ABORTION; CHILDREN; ROLES;
D O I：
10.1016/j.humimm.2013.06.010
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The number of HIV-infected young women has been increasing since the beginning of the AIDS epidemic. The objective of the present study was to investigate the impact of anti-retroviral treatment (ART) of HIV1-infected pregnant women (PW) on cytokine profile of uninfected neonates. Our results demonstrated that higher levels of IL-1 beta and TNF-alpha associated with lower IL-10 production were detected in the plasma obtained from neonates born from ART-treated PW. Furthermore, the production of TNF-alpha and IFN-gamma was also significantly higher in polyclonally-activated T cells from those neonates. This elevated pro-inflammatory pattern detected by these activated-T cells was not associated to HIV-1 antigens sensitization. Finally, ART-exposed neonates showed to be born with lower weight, and it was inversely correlated with maternal peripheral TNF-a level. In summary, the data presented here suggest a significant disturbance in cytokine network of HIV-1-uninfected neonates exposed to potent anti-retroviral schemes during pregnancy. (C) 2013 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：1051 / 1056
页数：6
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