Comparative hypoglycemic activity of different extracts of Teucrium stocksianum in diabetic rabbits

被引：9
|
作者：
Alamgeer [1 ]
Rashid, Muhammad [2 ]
Bashir, Sajid [1 ]
Mushtaq, Muhammad Naveed [1 ]
Khan, Hafeez Ullah [1 ]
Malik, Muhammad Nasir Hayat [1 ]
Qayyum, Abdul [1 ]
Rahaman, Muhammad Shafeeq Ur [1 ]
机构：
[1] Univ Sargodha, Fac Pharm, Sargodha, Pakistan
[2] Univ Faisalabad, Sch Pharm, Faisalabad, Pakistan
来源：
BANGLADESH JOURNAL OF PHARMACOLOGY | 2013年 / 8卷 / 02期
关键词：
Blood glucose; Diabetes; Teucrium stocksianum; INSULIN;
D O I：
10.3329/bjp.v8i2.14519
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In the present study crude powder and various extracts of Teucrium stocksianum were evaluated for antidiabetic effect in alloxan-induced diabetic rabbits. Crude extract significantly reduced blood glucose level of normal and diabetic rabbits. The results were comparable with standard drug glibenclamide. Ethyl acetate extract (500 mg/kg) produced maximum decrease in blood glucose level among all the extracts and was selected for further study. Ethyl acetate extract significantly inhibited rise in glucose level in normal rabbits after an oral glucose load. The extract showed synergistic effect with different doses of insulin. Serum insulin level of diabetic rabbits was also significantly increased by the extract. HbA1c level was significantly (p<0.05) reduced whereas hemoglobin level was significantly increased by the extract. It is concluded that ethyl acetate extract may be a good remedy to manage diabetes and its complications.
引用
收藏
页码：186 / 193
页数：8
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