Murine NKT cells produce Th17 cytokine interleukin-22

被引：80
|
作者：
Goto, Megumi [1 ]
Murakawa, Masao [1 ]
Kadoshima-Yamaoka, Kumiko [1 ]
Tanaka, Yoshitaka [1 ]
Nagahira, Kazuhiro [1 ]
Fukuda, Yoshiaki [1 ]
Nishimura, Takashi [2 ]
机构：
[1] Asubio Pharma Co Ltd, Biomed Res Labs, Shimamoto, Osaka 6188503, Japan
[2] Hokkaido Univ Sapporo, Inst Med Genet, Sect Dis Control, Div Immunoregulat, Sapporo, Hokkaido, Japan
来源：
CELLULAR IMMUNOLOGY | 2009年 / 254卷 / 02期
关键词：
Interleukin-22 (IL-22); NKT cells; Cytokine; Th17; cells; KILLER T-CELLS; INDUCIBLE FACTOR; SKIN INFLAMMATION; GENE-EXPRESSION; IL-TIF; IL-22; IL-10; HEPATITIS; IDENTIFICATION; ACTIVATION;
D O I：
10.1016/j.cellimm.2008.10.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Natural killer T (NKT) cells are known to produce Th17 cytokine IL-17 in addition to Th1/2 cytokines. In this study, the ability of NKT cells to produce IL-22, another Th17 cytokine, was examined in mice. When murine spleen cells were stimulated with alpha-galactosyl ceramide, a ligand for NKT cells, not only Th1/2 cytokines (IFN-gamma, IL-4) but Th17 cytokines (IL-17, IL-22) were produced. NKT cells isolated from splenocytes released IL-17 and IL-22 following CD3, CD3/IL-2 or CD3/CD28 stimulation, in which CD3/CD28 costimulation was most effective. Production of IL-17 and IL-22 in CD4+ and CD8+ T cells from splenocytes was little, if any. even after CD3/CD28 costimulation. Treatment with IL-6/TGF-beta decreased CD3/CD28-stimulated production of IL-22, but not that of IL-17, in NKT cells. These findings show for the first time that NKT cells are a cell source of IL-22, and that expression of two Th17 cytokines might be regulated in NKT cells by different mechanisms. (c) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：81 / 84
页数：4
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