Analysis of genetic aberrations in uterine adenomyosis using comparative genomic hybridization

被引：0
|
作者：
Wang, PH
Shyong, WY
Lin, CH
Chen, YJ
Li, YF
Chao, HT
Yuan, CC
机构：
[1] Vet Gen Hosp, Dept Obstet & Gynecol, Taipei 11217, Taiwan
[2] Natl Yang Ming Univ, Inst Microbiol & Immunol, Taipei 112, Taiwan
[3] Natl Yang Ming Univ, Ctr Gen Educ, Taipei 112, Taiwan
来源：
ANALYTICAL AND QUANTITATIVE CYTOLOGY AND HISTOLOGY | 2002年 / 24卷 / 01期
关键词：
genomic hybridization; genes; adenomyosis; uterine diseases; genetic aberrations;
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
OBJECTIVE: To use comparative genomic hybridization (CGH) to analyze frozen tissues from adenomyosis cases to discover and map genomic regions for chromosomal gains and losses. STUDY DESIGN: In a retrospective study, zipper and lower threshold values of 1.20 and 0.80, respectively, were used to define positive findings. RESULTS: No positive recurrent gene copy number alterations were detected in the 25 cases of pathologically proven adenomyosis. CONCLUSION: Although CGH is extremely useful in investigating candidate genes in the development of adenomyosis, CGH was not useful in this study. Genetic changes might be indeed extremely rare in adenomyosis, or CGH was not sensitive enough to detect candidate genes.
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页码：1 / 6
页数：6
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