Prenatal Developmental Toxicity Testing of Petroleum Substances Using the Zebrafish Embryotoxicity Test
被引:16
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作者:
Kamelia, Lenny
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机构:
Wageningen Univ & Res, Div Toxicol, POB 8000, NL-6700 EA Wageningen, NetherlandsWageningen Univ & Res, Div Toxicol, POB 8000, NL-6700 EA Wageningen, Netherlands
Kamelia, Lenny
[1
]
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机构:
Brugman, Sylvia
[2
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de Haan, Laura
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h-index: 0
机构:
Wageningen Univ & Res, Div Toxicol, POB 8000, NL-6700 EA Wageningen, NetherlandsWageningen Univ & Res, Div Toxicol, POB 8000, NL-6700 EA Wageningen, Netherlands
de Haan, Laura
[1
]
Ketelslegers, Hans B.
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机构:
European Petr Refiners Assoc, Concawe Div, Brussels, BelgiumWageningen Univ & Res, Div Toxicol, POB 8000, NL-6700 EA Wageningen, Netherlands
Ketelslegers, Hans B.
[3
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Rietjens, Ivonne M. C. M.
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机构:
Wageningen Univ & Res, Div Toxicol, POB 8000, NL-6700 EA Wageningen, NetherlandsWageningen Univ & Res, Div Toxicol, POB 8000, NL-6700 EA Wageningen, Netherlands
Rietjens, Ivonne M. C. M.
[1
]
Boogaard, Peter J.
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机构:
Wageningen Univ & Res, Div Toxicol, POB 8000, NL-6700 EA Wageningen, Netherlands
Shell Int BV, Shell Hlth, The Hague, NetherlandsWageningen Univ & Res, Div Toxicol, POB 8000, NL-6700 EA Wageningen, Netherlands
Boogaard, Peter J.
[1
,4
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机构:
[1] Wageningen Univ & Res, Div Toxicol, POB 8000, NL-6700 EA Wageningen, Netherlands
POLYCYCLIC AROMATIC-HYDROCARBONS;
STEM-CELL TEST;
WHOLE-EMBRYO CULTURE;
CLARIFIED SLURRY OIL;
IN-VITRO;
CARDIAC TOXICITY;
TEST EST;
VALIDATION;
MODEL;
ASSAY;
D O I:
10.14573/altex.1808121
中图分类号:
R-3 [医学研究方法];
R3 [基础医学];
学科分类号:
1001 ;
摘要:
The present study evaluates the applicability of the zebrafish embryotoxicity test (ZET) to assess prenatal developmental toxicity (PDT) potency of the DMSO-extracts of 9 petroleum substances (PS), with variable polycyclic aromatic hydrocarbon (PAH) content, and 2 gas-to-liquid (GTL) products, without any PAHs but otherwise similar properties to PS. All PS extracts induced concentration-dependent PDT as quantified in the ZET and this potency is associated with their 3-5 ring PAH content. In contrast and as expected, GTL products did not induce any effect in the ZET. The potencies obtained in the ZET correlated with those previously reported for the embryonic stem cell test (EST) (R-2 = 0.61), while the correlation with potencies reported in in vivo studies was higher for the EST (R-2 = 0.85) than the ZET (R-2 = 0.69). Combining the results of the ZET with those previously reported for the EST (Kamelia et al., 2017), the aryl hydrocarbon (AhR) CALUX assay (Kamelia et al., 2018), and the PAH content, ranked and clustered the test compounds in line with their in vivo potencies and chemical characteristics. Our findings indicate that the ZET does not outperform the EST as a stand-alone assay for testing PDT of PS, but confirm the hypothesis that PAHs are the major inducers of PDT by some PS, while they also indicate that the ZET is a useful addition to a battery of in vitro tests able to predict the in vivo PDT of PS.
机构:
Shell Int BV, Shell Hlth, NL-2501 AN The Hague, Netherlands
Wageningen Univ, Div Toxicol, NL-6700 AP Wageningen, NetherlandsShell Int BV, Shell Hlth, NL-2501 AN The Hague, Netherlands
Tsitou, Polyxeni
Heneweer, Marjoke
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机构:
Shell Int BV, Shell Hlth, NL-2501 AN The Hague, NetherlandsShell Int BV, Shell Hlth, NL-2501 AN The Hague, Netherlands
Heneweer, Marjoke
Boogaard, Peter J.
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机构:
Shell Int BV, Shell Hlth, NL-2501 AN The Hague, NetherlandsShell Int BV, Shell Hlth, NL-2501 AN The Hague, Netherlands
机构:
Rudjer Boskovic Inst, Div Mat Chem, Lab Biotechnol Aquaculture, Bijenicka Cesta 54, Zagreb, Croatia
Rudjer Boskovic Inst, Ctr Excellence Marine Bioprospecting BioProCro, Bijenicka Cesta 54, Zagreb, CroatiaRudjer Boskovic Inst, Div Mat Chem, Lab Biotechnol Aquaculture, Bijenicka Cesta 54, Zagreb, Croatia
Babic, Sanja
Barisic, Josip
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机构:
Rudjer Boskovic Inst, Div Mat Chem, Lab Biotechnol Aquaculture, Bijenicka Cesta 54, Zagreb, Croatia
Rudjer Boskovic Inst, Ctr Excellence Marine Bioprospecting BioProCro, Bijenicka Cesta 54, Zagreb, CroatiaRudjer Boskovic Inst, Div Mat Chem, Lab Biotechnol Aquaculture, Bijenicka Cesta 54, Zagreb, Croatia
Barisic, Josip
Stipanicev, Drazenka
论文数: 0引用数: 0
h-index: 0
机构:
Cent Water Management Lab, Croatian Waters, Ul Grada Vukovara 220, Zagreb, CroatiaRudjer Boskovic Inst, Div Mat Chem, Lab Biotechnol Aquaculture, Bijenicka Cesta 54, Zagreb, Croatia
Stipanicev, Drazenka
Repec, Sinisa
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机构:
Cent Water Management Lab, Croatian Waters, Ul Grada Vukovara 220, Zagreb, CroatiaRudjer Boskovic Inst, Div Mat Chem, Lab Biotechnol Aquaculture, Bijenicka Cesta 54, Zagreb, Croatia
Repec, Sinisa
Lovric, Mario
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机构:
Know Ctr, Inffeldgasse 13-6, A-8010 Graz, Austria
Rudjer Boskovic Inst, NMR Ctr, Bijenicka Cesta 54, Zagreb, CroatiaRudjer Boskovic Inst, Div Mat Chem, Lab Biotechnol Aquaculture, Bijenicka Cesta 54, Zagreb, Croatia
Lovric, Mario
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机构:
Malev, Olga
Martinovic-Weigelt, Dalma
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机构:
Univ St Thomas, Dept Biol, Mail OWS 390,2115 Summit Ave, St Paul, MN 55105 USARudjer Boskovic Inst, Div Mat Chem, Lab Biotechnol Aquaculture, Bijenicka Cesta 54, Zagreb, Croatia
Martinovic-Weigelt, Dalma
Coz-Rakovac, Rozelindra
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机构:
Rudjer Boskovic Inst, Div Mat Chem, Lab Biotechnol Aquaculture, Bijenicka Cesta 54, Zagreb, Croatia
Rudjer Boskovic Inst, Ctr Excellence Marine Bioprospecting BioProCro, Bijenicka Cesta 54, Zagreb, CroatiaRudjer Boskovic Inst, Div Mat Chem, Lab Biotechnol Aquaculture, Bijenicka Cesta 54, Zagreb, Croatia
Coz-Rakovac, Rozelindra
Klobucar, Goran
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机构:
Univ Zagreb, Fac Sci, Dept Biol, Div Zool, Rooseveltov Trg 6, Zagreb, CroatiaRudjer Boskovic Inst, Div Mat Chem, Lab Biotechnol Aquaculture, Bijenicka Cesta 54, Zagreb, Croatia