Prostaglandin E2 Signaling: Alternative Target for Glioblastoma?

被引：62
|
作者：
Jiang, Jianxiong [1 ]
Qiu, Jiange [1 ,2 ,3 ]
Li, Qianqian [1 ]
Shi, Zhi [2 ,3 ]
机构：
[1] Univ Cincinnati, Acad Hlth Ctr, James L Winkle Coll Pharm, Div Pharmaceut Sci, Cincinnati, OH 45267 USA
[2] Jinan Univ, Coll Life Sci & Technol, Natl Engn Res Ctr Genet Med, Guangdong Prov Key Lab Bioengn Med,Dept Cell Biol, Guangzhou 510632, Guangdong, Peoples R China
[3] Jinan Univ, Coll Life Sci & Technol, Guangdong Prov Key Lab Bioengn Med, Natl Engn Res Ctr Genet Med,Inst Biomed, Guangzhou 510632, Guangdong, Peoples R China
来源：
TRENDS IN CANCER | 2017年 / 3卷 / 02期
基金：
美国国家卫生研究院; 中国国家自然科学基金;
关键词：
GLIOMA-CELL GROWTH; RECEPTOR EP2; E SYNTHASE-1; INFLAMMATION; MICROGLIA; SURVIVAL; CANCER;
D O I：
10.1016/j.trecan.2016.12.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Elevated cyclooxygenase-2 (COX-2) and the associated inflammation within the brain contribute to glioblastoma development. However, medical use of COX inhibitors in glioblastoma treatment has been limited due to their well-documented vascular toxicity and inconsistent outcomes from recent human studies. Prostaglandin E2 (PGE2) has emerged as a principal mediator for COX-2 cascade-driven gliomagenesis. Are PGE(2) terminal synthases and receptors feasible therapeutic targets for glioblastoma?
引用
收藏
页码：75 / 78
页数：4
相关论文
共 50 条
  • [11] Prostaglandin E2 a Therapeutic Target of Lung Inflammation in Cystic Fibrosis?
    O'Callaghan, G.
    Ronan, N.
    McCarthy, Y.
    Chroinin, M. Ni
    Mullane, D.
    Murphy, D. M.
    Eustace, J.
    Houston, A.
    Plant, B. J.
    IRISH JOURNAL OF MEDICAL SCIENCE, 2015, 184 : S538 - S539
  • [12] Prostaglandin E2 as a potent therapeutic target for treatment of colon cancer
    Karpisheh, Vahid
    Nikkhoo, Afshin
    Hojjat-Farsangi, Mohammad
    Namdar, Afshin
    Azizi, Gholamreza
    Ghalamfarsa, Ghasem
    Sabz, Gholamabas
    Yousefi, Mehdi
    Yousefi, Bahman
    Jadidi-Niaragh, Farhad
    PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2019, 144
  • [13] The Effect Of Prostaglandin E2 Signaling On Myogenic Differentiation And Muscle Contractility
    Mo, Chenglin
    Brotto, Leticia
    Brotto, Marco
    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2014, 46 (05): : 308 - 308
  • [14] Prostaglandin E2/EP Signaling in the Tumor Microenvironment of Colorectal Cancer
    Mizuno, Rei
    Kawada, Kenji
    Sakai, Yoshiharu
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (24)
  • [15] Disrupting prostaglandin E2 signaling to reverse treatment resistance in cancer
    Markosyan, Nune
    Quinones, Liz
    Aurora, Charu
    Joshi, Nikhil
    Kim, Ilkyu
    Stanger, Ben Z.
    Vonderheide, Robert H.
    CANCER RESEARCH, 2022, 82 (12)
  • [16] Prostaglandin E2 augments IL-10 signaling and function
    Cheon, HyeonJoo
    Rho, Young Hee
    Choi, Seong Jae
    Lee, Young Ho
    Song, Gwan Gyu
    Sohn, Jeongwon
    Won, Nam Hee
    Ji, Jong Dae
    JOURNAL OF IMMUNOLOGY, 2006, 177 (02): : 1092 - 1100
  • [17] The Emerging Therapeutic Role of Prostaglandin E2 Signaling in Pulmonary Hypertension
    Ye, Lan
    Wang, Bing
    Xu, Hu
    Zhang, Xiaoyan
    METABOLITES, 2023, 13 (11)
  • [18] Prostaglandin E2 Inhibits BMP Signaling and Delays Chondrocyte Maturation
    Clark, Christine A.
    Li, Tian-Fang
    Kim, Kyung-Ok
    Drissi, Hicham
    Zuscik, Michael J.
    Zhang, Xinping
    O'Keefe, Regis J.
    JOURNAL OF ORTHOPAEDIC RESEARCH, 2009, 27 (06) : 785 - 792
  • [19] Prostaglandin E2 receptor signaling in dental pulp cells.
    Chang, M. -C.
    Jeng, J. -H.
    JOURNAL OF DENTAL RESEARCH, 2003, 82 : B186 - B186
  • [20] Prostaglandin E2, an Immunoactivator
    Sakata, Daiji
    Yao, Chengcan
    Narumiya, Shuh
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, 112 (01) : 1 - 5
12345