T Cell Receptor Specificity, Cross-Reactivity, and MHC Restriction are Inextricably Linked and Result from Cooperative Engagement of the Composite Peptide/MHC Surface

被引：0
|
作者：
Baker, Brian M. [1 ]
Piepenbrink, Kurt H. [1 ]
Blevins, Sydney J. [1 ]
机构：
[1] Univ Notre Dame, Notre Dame, IN 46556 USA
来源：
BIOPHYSICAL JOURNAL | 2013年 / 104卷 / 02期
关键词：
D O I：
10.1016/j.bpj.2012.11.2249
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
引用
收藏
页码：403A / 403A
页数：1
相关论文
共 50 条
  • [11] The basis for limited specificity and MHC restriction in a T cell receptor interface
    Kurt H. Piepenbrink
    Sydney J. Blevins
    Daniel R. Scott
    Brian M. Baker
    Nature Communications, 4
  • [12] How an alloreactive T-cell receptor achieves peptide and MHC specificity
    Wang, Yuan
    Singh, Nishant K.
    Spear, Timothy T.
    Hellman, Lance M.
    Piepenbrink, Kurt H.
    McMahan, Rachel H.
    Rosen, Hugo R.
    Vander Kooi, Craig W.
    I. Nishimura, Michael
    Baker, Brian M.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (24) : E4792 - E4801
  • [13] Accounting for Specificity and Cross-Reactivity in T Cell Receptor Molecular Recognition
    Baker, Brian M.
    BIOPHYSICAL JOURNAL, 2018, 114 (03) : 219A - 219A
  • [14] Analysis of serial engagement and peptide-MHC transport in T cell receptor microclusters
    Dushek, Omer
    Coombs, Daniel
    BIOPHYSICAL JOURNAL, 2008, 94 (09) : 3447 - 3460
  • [15] Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: Insights into MHC bias and antigen specificity
    Maynard, J
    Petersson, K
    Wilson, DH
    Adams, EJ
    Blondelle, SE
    Boulanger, MJ
    Wilson, DB
    Garcia, KC
    IMMUNITY, 2005, 22 (01) : 81 - 92
  • [16] A single T cell receptor recognizes structurally distinct MHC/peptide complexes with high specificity
    Tallquist, MD
    Yun, TJ
    Pease, LR
    JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (03): : 1017 - 1026
  • [17] ANTIGENIC CROSS-REACTIVITY AND LACK OF MHC-RESTRICTION BY MYELIN BASIC-PROTEIN (MBP)-REACTIVE HUMAN T-CELL CLONES
    RICHERT, J
    ROBINSON, E
    FAERBER, M
    JOHNSON, A
    COHN, M
    HUGER, A
    HURLEY, CK
    FASEB JOURNAL, 1992, 6 (05): : A1685 - A1685
  • [18] Molecular definition of class I MHC restriction of a peptide-specific αβ T cell receptor.
    Turner, RV
    Biddison, WE
    FASEB JOURNAL, 1999, 13 (04): : A625 - A625
  • [19] Initiation of signal transduction through the T cell receptor requires the peptide multivalent engagement of MHC ligands
    Boniface, JJ
    Rabinowitz, JD
    Wülfing, C
    Hampl, J
    Reich, Z
    Altman, JD
    Kantor, RM
    Beeson, C
    McConnell, HM
    Davis, MM
    IMMUNITY, 1998, 9 (04) : 459 - 466
  • [20] T-CELL RECEPTOR MHC CLASS-I PEPTIDE INTERACTIONS - AFFINITY, KINETICS, AND SPECIFICITY
    FISHER, RJ
    FIVASH, M
    SCIENCE, 1995, 268 (5207) : 115 - 117
12345