Genetic analysis of twelve X-chromosomal STRs in Japanese and Chinese populations

被引:34
|
作者
Uchigasaki, Seisaku [1 ]
Tie, Jian [1 ]
Takahashi, Daisuke [1 ]
机构
[1] Nihon Univ Sch Med, Dept Social Med, Div Legal Med, Itabashi Ku, Tokyo 1738610, Japan
关键词
X chromosome; STR; Japanese; Chinese; Haplotype; Genetic diversity; FORENSIC PURPOSES; POLYMORPHISMS;
D O I
10.1007/s11033-012-2394-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We investigated the genetic markers of twelve X-STR loci in 670 healthy, unrelated Japanese (438 men and 232 women) from Tokyo and 488 Chinese (263 men and 225 women) from Shenyang, using the Investigator Argus X-12 kit. Allele and haplotype analyses of twelve X-STRs clustered into four linkage groups indicated that they are highly informative for forensic applications in Japanese and Chinese populations. Hardy-Weinberg equilibrium tests demonstrated no significant deviations in the two populations. Among the four closely linked X-STR trios, some haplotype unique to Japanese or Chinese population were detected. Haplotype diversity for each linkage group ranged from 0.9861 to 0.9968, showing high values in each of the study populations. The genetic distances between populations based on the 12 X-STR loci and the phylogenetic tree revealed long genetic distances between Asian and Caucasian populations and between Asian and African population (Moroccan). These results suggest that the twelve X-STR loci will contribute to forensic casework in Japanese and Chinese populations.
引用
收藏
页码:3193 / 3196
页数:4
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