Serum YKL-40 concentrations in patients with rheumatoid arthritis: relation to disease activity

被引:163
|
作者
Johansen, JS
Stoltenberg, M
Hansen, M
Florescu, A
Horslev-Petersen, K
Lorenzen, I
Price, PA
机构
[1] Univ Copenhagen, Hvidovre Hosp, Dept Rheumatol, DK-1168 Copenhagen, Denmark
[2] Univ Copenhagen, Rigshosp, Dept Internal Med TTA, DK-1168 Copenhagen, Denmark
[3] Univ Calif San Diego, Dept Biol 0368, La Jolla, CA 92093 USA
关键词
YKL-40; rheumatoid arthritis; disease activity; human cartilage glycoprotein-39;
D O I
10.1093/rheumatology/38.7.618
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. YKL-40, also called human cartilage glycoprotein-39, is secreted by chondrocytes, synovial cells, macrophages and neutrophils. Studies have shown that YKL-40 is an autoantigen in rheumatoid arthritis (RA). We evaluated whether serum YKL-40 was related to disease activity in patients with RA. Methods. Serum YKL-40 was determined by radioimmunoassay in 156 patients with RA during a 1 yr longitudinal study. Results. Serum YKL-40 was increased in 54% of the patients with clinically active disease. Patients with clinically active disease initially who became inactive after 12 months had a significant decrease in serum YKL-40 (-30%, P < 0.002) and patients who changed from inactive to active disease had an increase in serum YKL-40. Patients who remained active had unchanged serum YKL-40 during the study. Serum YKL-40 decreased rapidly (-24% after 7 days, P < 0.01) during prednisolone therapy, and more slowly in patients treated with methotrexate only (-15% after 60 days, P < 0.01). Patients with early RA (disease duration <3 yr, n = 50) and a persistently elevated serum YKL-40 were at risk of radiological disease progression as determined by Larsen score. Conclusion. Serum YKL-40 varies according to disease activity in RA, but provides in some respect information different from conventional markers. Our previous studies are consistent with a local release of YKL-40 in the arthritic joint followed by a secondary increase in serum YKL-40. YKL-40 may prove to be a new tool for the study of disease activity and pathophysiology of RA.
引用
收藏
页码:618 / 626
页数:9
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