Synthesis and potential application of acylhydrazone functionalized linear poly(glycidol)s

被引：4
|
作者：
Li, Yusi [1 ]
Chen, Qianqian [1 ]
Hu, Lei [1 ]
机构：
[1] Jiangsu Univ, Sch Pharm, 301 Xuefu Rd, Zhenjiang, Peoples R China
来源：
JOURNAL OF MOLECULAR LIQUIDS | 2022年 / 367卷
关键词：
Acylhydrazone linear poly(glycidol); Polymer surfactant; Surface activity; Hemolytic activity; Drug carrier; POLYMERIC SURFACTANTS; POLY(ETHYLENE; POLYGLYCEROL;
D O I：
10.1016/j.molliq.2022.120458
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Acylhydrazone functionalized linear poly(glycidol) (HLPG) polymers were synthesized as novel nonionic surfactants, where acylhydrazone bond was used as convenient connection to conjugate hydrophobic alkyl chains of various lengths. A comprehensive study of their surface property, foamability/foaming sta-bility and biocompatibility allowed us to establish the corresponding structure-activity profile, which indicated that the physical and biological properties of those surfactants were closely related to the length of attached alkyl side chains. In addition, the drug encapsulation/release tests were conducted to further demonstrate the utility of this type of materials. Thus, our study offered as a valuable reference for their potential practical applications. (c) 2022 Elsevier B.V. All rights reserved.
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页数：8
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