Synthesis and potential application of acylhydrazone functionalized linear poly(glycidol)s

Acylhydrazone functionalized linear poly(glycidol) (HLPG) polymers were synthesized as novel nonionic surfactants, where acylhydrazone bond was used as convenient connection to conjugate hydrophobic alkyl chains of various lengths. A comprehensive study of their surface property, foamability/foaming sta-bility and biocompatibility allowed us to establish the corresponding structure-activity profile, which indicated that the physical and biological properties of those surfactants were closely related to the length of attached alkyl side chains. In addition, the drug encapsulation/release tests were conducted to further demonstrate the utility of this type of materials. Thus, our study offered as a valuable reference for their potential practical applications. (c) 2022 Elsevier B.V. All rights reserved.