MiRNA-based Therapeutics for Lung Cancer

被引：70
|
作者：
Wu, Miaowei [1 ]
Wang, Guosheng [2 ]
Tian, Wei [1 ]
Deng, Yongchuan [1 ]
Xu, Yibing [2 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Surg Oncol, 88 Jiefang Rd, Hangzhou 310009, Zhejiang, Peoples R China
[2] Zhejiang Univ, Inst Translat Med, Sch Med, Hangzhou 310029, Zhejiang, Peoples R China
来源：
CURRENT PHARMACEUTICAL DESIGN | 2017年 / 23卷 / 39期
基金：
中国国家自然科学基金;
关键词：
miRNA; oncogene; tumor suppressor; drug resistance; lung cancer; therapy; TUMOR-SUPPRESSOR; GEFITINIB-RESISTANCE; MICRORNA EXPRESSION; PROGNOSTIC-SIGNIFICANCE; MESENCHYMAL TRANSITION; CELLS; GROWTH; LET-7; PROLIFERATION; INVASION;
D O I：
10.2174/1381612823666170714151715
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Background: miRNA, a small non-coding RNA molecule containing about 22 nucleotides, functions in RNA silencing and post-transcriptional regulation of gene expression. With these qualities, miRNAs modulate multiple signaling pathways involved in cancer development, such as cellular proliferation, apoptosis, and migration. Methods: The goal of this review is to discuss possible miRNAs-based therapeutic strategies, through defining performance of miRNAs in carcinogenesis, in particular in lung cancer. Results: miRNA, a non-coding RNA, is divided into two main types: tumor suppressor miRNAs and oncogenic miRNAs. In addition, special processed miRNAs can be an assistant therapeutic tool. Conclusion: In order to develope antitumor therapy, miRNAs-based therapeutic strategies are worth of deeper studies. In this process, the stability, effectiveness, and side effects should be considered.
引用
收藏
页码：5989 / 5996
页数：8
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