Subpopulation Analysis of Heteroresistance to Fluoroquinolone in Mycobacterium tuberculosis Isolates from Beijing, China

被引：34

作者：

Zhang, Xiaobing ^{[1
]}

Zhao, Bing ^{[2
]}

Liu, Liguo ^{[1
]}

Zhu, Yafang ^{[1
]}

Zhao, Yanlin ^{[2
]}

Jin, Qi ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Inst Pathogen Biol, State Key Lab Mol Virol & Genet Engn, Beijing 100730, Peoples R China

[2] Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2012年 / 50卷 / 04期

关键词：

RESISTANCE; SUSCEPTIBILITY; MUTATIONS; RIFAMPIN; GYRASE;

D O I：

10.1128/JCM.05793-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The presence of heteroresistance was represented by 23% of 235 fluoroquinolone (FQ)-resistant Mycobacterium tuberculosis isolates in Beijing, China, from 2008 to 2010. The main mechanism of FQ heteroresistance is due to the segregation of a single M. tuberculosis strain in patients; the majority of isolates with multidrug-resistant tuberculosis contained a mixture of bacterial subpopulations consisting of various mutant types, suggesting that the improper use of FQ is the major cause of FQ resistance.

引用

页码：1471 / 1474

页数：4

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