Insights into channel dysfunction from modelling and molecular dynamics simulations

被引:9
|
作者
Musgaard, Maria [1 ]
Paramo, Teresa [1 ]
Domicevica, Laura [1 ]
Andersen, Ole Juul [1 ]
Biggin, Philip C. [1 ]
机构
[1] Univ Oxford, Dept Biochem, South Parks Rd, Oxford OX1 3QU, England
基金
英国生物技术与生命科学研究理事会;
关键词
Mutation; Simulation; Computational; Membrane protein; Ion channel; TRANSMEMBRANE CONDUCTANCE REGULATOR; ALPHA-1 GLYCINE RECEPTORS; NUCLEOTIDE-BINDING DOMAIN; MEMBRANE-SPANNING DOMAINS; X-RAY-STRUCTURE; CRYSTAL-STRUCTURE; DELTA-F508; MUTATION; POTASSIUM CHANNELS; ATOMIC-STRUCTURE; VOLTAGE SENSOR;
D O I
10.1016/j.neuropharm.2017.06.030
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Developments in structural biology mean that the number of different ion channel structures has increased significantly in recent years. Structures of ion channels enable us to rationalize how mutations may lead to channelopathies. However, determining the structures of ion channels is still not trivial, especially as they necessarily exist in many distinct functional states. Therefore, the use of computational modelling can provide complementary information that can refine working hypotheses of both wild type and mutant ion channels. The simplest but still powerful tool is homology modelling. Many structures are available now that can provide suitable templates for many different types of ion channels, allowing a full three-dimensional interpretation of mutational effects. These structural models, and indeed the structures themselves obtained by X-ray crystallography, and more recently cryo-electron microscopy, can be subjected to molecular dynamics simulations, either as a tool to help explore the conformational dynamics in detail or simply as a means to refine the models further. Here we review how these approaches have been used to improve our understanding of how diseases might be linked to specific mutations in ion channel proteins. This article is part of the Special Issue entitled 'Channelopathies.' (C) 2017 The Authors. Published by Elsevier Ltd.
引用
收藏
页码:20 / 30
页数:11
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