Prevalence and risk factors for cervical intraepithelial neoplasia among HIV-infected women

被引:0
|
作者
Pereira Teixeira, Nara Chartuni [2 ]
Labanca Araujo, Angela Cristina [2 ]
Correa, Christine Miranda [3 ]
da Costa Lodi, Claudia Teixeira [4 ]
Miranda Lima, Maria Ines [2 ]
Carvalho, Nara de Oliveira [1 ]
del Castillo, Dora Mendez [1 ]
Melo, Victor Hugo [1 ]
机构
[1] Univ Fed Minas Gerais, Sch Med, Ctr Res & Diag NUPAD, BR-30130100 Belo Horizonte, MG, Brazil
[2] Dept Hlth Serv, Belo Horizonte, MG, Brazil
[3] Dept Hlth Serv, Tres Rios, MG, Brazil
[4] Fac Ciencias Med Minas Gerais, Belo Horizonte, MG, Brazil
来源
关键词
HIV; DNA probes; HPV; Cervical intraepithelial neoplasia; Immunosuppression; HUMAN-IMMUNODEFICIENCY-VIRUS; HUMAN-PAPILLOMAVIRUS INFECTION; LESIONS; ABNORMALITIES;
D O I
10.1590/S1413-86702012000200010
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Objectives: To evaluate the prevalence and the risk factors for cervical intraepithelial neoplasia (CIN) among HIV-infected women. Methods: Cross-sectional study of 494 HIV-infected women in Brazil, between 1998 and 2008. Gynecologic exam was performed, and samples were collected for cervical cytology and for HPV DNA detection. Cervical biopsy was carried out when indicated. HPV infection, CD4 T-lymphocyte count and HIV viral load were compared with cervical histopathology. Univariate and multivariate statistical analyses were performed to evaluate the statistical association of several risk factors. Results: CIN prevalence detected by histopathology was 23.4% (6% of CIN2/3 and 17.4% cases of CIN1). Multivariate analysis confirmed an independent association of CIN with CD4 T-lymphocyte count below 200 cells/mm(3) (OR 5.0, 95% CI 2.5-10.1), with a positive detection of HPV DNA (OR 2.0, 95% CI 1.2-3.5), and with age <= 34 years old (OR 1.5, 95% CI 1.0-2.4). HIV viral load and antiretroviral use were not independent risk factors for CIN. Conclusions: Severity of immunosupression, presence of HPV infection and younger age are strong predictors of CIN among HIV-infected women. (C) 2012 Elsevier Editora Ltda. All rights reserved.
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收藏
页码:164 / 169
页数:6
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