Reduced Intensity Conditioning in Allogeneic Stem Cell Transplantation for AML With Down Syndrome

被引：11

作者：

Muramatsu, Hideki ^{[1
]}

Sakaguchi, Hirotoshi ^{[1
,2
]}

Taga, Takashi ^{[3
]}

Tabuchi, Ken ^{[4
]}

Adachi, Souichi ^{[5
]}

Inoue, Masami ^{[6
,7
]}

Kitoh, Toshiyuki ^{[8
]}

Suminoe, Aiko ^{[9
]}

Yabe, Hiromasa ^{[10
]}

Azuma, Eichi ^{[11
]}

Shioda, Yoko ^{[12
]}

Ogawa, Atsushi ^{[13
]}

Kinoshita, Akitoshi ^{[14
]}

Kigasawa, Hisato ^{[4
]}

Osugi, Yuko ^{[15
]}

Koike, Kazutoshi ^{[16
]}

Kawa, Keisei ^{[6
,7
]}

Kato, Koji ^{[2
]}

Atsuta, Yoshiko ^{[17
]}

Kudo, Kazuko ^{[18
]}

机构：

[1] Nagoya Univ, Dept Pediat, Grad Sch Med, Nagoya, Aichi 4668550, Japan

[2] Japanese Red Cross Nagoya First Hosp, Dept Hematol & Oncol, Childrens Med Ctr, Nagoya, Aichi, Japan

[3] Shiga Univ Med Sci, Dept Pediat, Otsu, Shiga 52021, Japan

[4] Kanagawa Childrens Hosp, Dept Hematol Oncol, Yokohama, Kanagawa, Japan

[5] Kyoto Univ, Grad Sch Med, Kyoto, Japan

[6] Osaka Med Ctr, Dept Hematol Oncol, Osaka, Japan

[7] Res Inst Maternal & Child Hlth, Osaka, Japan

[8] Shiga Med Ctr Children, Dept Hematol Oncol, Moriyama, Japan

[9] Kyushu Univ, Dept Pediat, Grad Sch Med, Fukuoka 812, Japan

[10] Tokai Univ, Sch Med, Dept Cell Transplantat & Regenerat Med, Isehara, Kanagawa 25911, Japan

[11] Mie Univ, Dept Pediat, Grad Sch Med, Tsu, Mie 514, Japan

[12] Natl Ctr Child Hlth & Dev, Div Hematol Oncol, Tokyo, Japan

[13] Niigata Canc Ctr Hosp, Dept Pediat, Niigata, Japan

[14] St Marianna Univ, Dept Pediat, Sch Med, Kawasaki, Kanagawa, Japan

[15] Osaka City Gen Hosp, Dept Pediat Hematol Oncol, Osaka, Japan

[16] Ibaraki Childrens Hosp, Dept Hematol Oncol, Mito, Ibaraki, Japan

[17] Nagoya Univ, Grad Sch Med, Dept Hematopoiet Stem Cell Transplantat Data Mana, Nagoya, Aichi 4668550, Japan

[18] Shizuoka Childrens Hosp, Div Hematol & Oncol, Shizuoka, Japan

来源：

PEDIATRIC BLOOD & CANCER | 2014年 / 61卷 / 05期

关键词：

acute myeloid leukemia; allogeneic stem cell transplantation; Down syndrome; reduced intensity conditioning; ACUTE MYELOID-LEUKEMIA; CHILDREN; REGIMEN; TOXICITY;

D O I：

10.1002/pbc.24883

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Allogeneic hematopoietic stem cell transplantation (HSCT) has not been widely used in patients with acute myeloid leukemia (AML) and Down syndrome (DS) due to fear of transplantation-related toxicity. A retrospective analysis of the outcome of allogeneic HSCT was conducted in 15 patients with AML and DS. The five patients transplanted with the reduced intensity conditioning (4 in complete remission (CR) and 1 in non-CR) had a significantly better survival rate than 10 patients transplanted with a conventional conditioning (4 in CR and 6 in non-CR) (3-year EFS (95% confidence interval): 80.0% (20.4-96.9%) vs. 10.0% (0.6%-35.8%), P=0.039). Pediatr Blood Cancer 2014;61:925-927. (c) 2013 Wiley Periodicals, Inc.

引用

页码：925 / 927

页数：3

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