Full-intensity and reduced-intensity allogeneic stem cell transplantation in AML

被引：35
|
作者：
Craddock, C. F. [1 ,2 ]
机构：
[1] Univ Hosp Birmingham, NHS Trust, Ctr Clin Haematol, Birmingham, W Midlands, England
[2] Univ Birmingham, Inst Canc Studies, Birmingham, W Midlands, England
来源：
BONE MARROW TRANSPLANTATION | 2008年 / 41卷 / 05期
关键词：
AML; reduced-intensity conditioning; GVL;
D O I：
10.1038/sj.bmt.1705975
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Allogeneic stem cell transplantation represents the most active form of anti-leukaemic therapy in acute myeloid leukaemia (AML). Advances in transplant technology and supportive care have resulted in improved outcomes in patients allografted using a myeloablative conditioning regimen. At the same time the use of reduced-intensity conditioning regimens has allowed an immunologically mediated graft-versus-leukaemia effect to be exploited in older patients who were previously ineligible for transplantation on the grounds of age or comorbidity. This coupled with the increased availability of alternative stem cell sources, in the form of either unrelated or cord blood donations, has established allogeneic transplantation as a key therapeutic strategy in the treatment of both younger and older adults with AML.
引用
收藏
页码：415 / 423
页数：9
相关论文
共 50 条
  • [1] Full-intensity and reduced-intensity allogeneic stem cell transplantation in AML
    C F Craddock
    [J]. Bone Marrow Transplantation, 2008, 41 : 415 - 423
  • [2] Current indications for reduced-intensity allogeneic stem cell transplantation
    Haddad, N
    Rowe, JM
    [J]. BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 2004, 17 (03) : 377 - 386
  • [3] Double reduced-intensity allogeneic haematopoietic stem cell transplantation
    Bay, J. -O.
    Cabrespine-Faugeras, A.
    Faucher, C.
    Tabrizi, R.
    Bordigoni, P.
    Bilger, K.
    Jouet, J. P.
    Renaud, M.
    Mialou, V.
    Robin, M.
    Kuentz, M.
    Chevallier, P.
    Dhedin, N.
    Huynh, A.
    Garban, F.
    Witz, F.
    Buzyn, A.
    De Revel, T.
    Galambrun, C.
    Deconnick, E.
    Contentin, N.
    Francois, S.
    Blaise, D.
    Michallet, M.
    [J]. BONE MARROW TRANSPLANTATION, 2009, 43 : S283 - S283
  • [4] Reduced-intensity allogeneic haematopoietic stem cell transplantation for lymphomas
    Bonifazi, F.
    Colaci, E.
    Bandini, G.
    Arpinati, M.
    Stanzani, M.
    Usai, S.
    Tazzari, P.
    Bontadini, A.
    Ricci, F.
    Dan, E.
    Taioli, S.
    Fina, M. P.
    Pellegrini, C.
    Zinzani, P.
    Baccarani, M.
    [J]. BONE MARROW TRANSPLANTATION, 2009, 43 : S216 - S217
  • [5] Standard and reduced-intensity allogeneic haematopoietic stem cell transplantation
    Michallet, M.
    Le, Q. -H.
    Dreger, P.
    Sobh, M.
    Niederwieser, D.
    Koza, V.
    Ruutu, T.
    Russell, N.
    Verdonck, L.
    Milligan, D.
    Dedhin, N.
    Kozak, T.
    Boogaerts, M.
    Finke, J.
    Tedone, N.
    Van Biezen, A.
    Brand, R.
    De Witte, T.
    [J]. BONE MARROW TRANSPLANTATION, 2009, 43 : S50 - S50
  • [6] Transplantation tolerance in allogeneic stem cell transplantation with reduced-intensity conditioning
    Laylor, R
    Dyson, P
    Dewchand, H
    Simpson, E
    Dazzi, F
    [J]. BONE MARROW TRANSPLANTATION, 2004, 33 : S74 - S75
  • [7] Lymphocyte reconstitution following reduced-intensity allogeneic stem cell transplantation
    Malcovati, L
    Pagnucco, G
    Bernasconi, P
    Vanelli, L
    Colombo, AA
    Caldera, D
    Varettoni, M
    Maiocchi, MA
    Tenore, A
    Mangiacavalli, S
    Lazzarino, M
    Alessandrino, EP
    [J]. BONE MARROW TRANSPLANTATION, 2002, 29 : S156 - S157
  • [8] Reduced-intensity allogeneic haematopoietic stem cell transplantation for multiple myeloma
    Kikuchi, T.
    Mori, T.
    Kato, J.
    Yamane, A.
    Ono, Y.
    Kunimoto, H.
    Okamoto, S.
    [J]. BONE MARROW TRANSPLANTATION, 2011, 46 : S264 - S264
  • [9] REDUCED-INTENSITY ALLOGENEIC STEM CELL TRANSPLANTATION IN PATIENTS WITH MYELODYSPLASTIC SYNDROMES
    Kuzmina, Larisa A.
    Parovichnikova, Elena N.
    Sorokina, Tamara V.
    Petinati, Natalia A.
    Drokov, Michail Y.
    Savchenko, Valeriy G.
    [J]. ANNALS OF HEMATOLOGY, 2013, 92 : S18 - S19
  • [10] Treatment of AML and MDS relapsing after reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation
    B Oran
    S Giralt
    D Couriel
    C Hosing
    E J Shpall
    E de Meis
    I F Khouri
    M Qazilbash
    P Anderlini
    P Kebriaei
    U Popat
    A Carrasco-Yalan
    R E Champlin
    M de Lima
    [J]. Leukemia, 2007, 21 : 2540 - 2544
12345