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- [33] Cliniclal benefit of 1-year certolizumab pegol(CZP) add-on therapy to methotrexate treatment in patients with early rheumatoid arthritiswas observed following CZP discontinuation: 2-year results of the C-OPERA study, a phase III randomised trial (vol 76, pg 1348, 2017) ANNALS OF THE RHEUMATIC DISEASES, 2022, 81 (09)