The mcr-1 Gene Has No Effect on Colistin Resistance When It Coexists with Inactivated mgrB Gene in Klebsiella pneumoniae

被引：12
|
作者：
Zhang, Huichuan [1 ,2 ]
Zhao, Dongdong [1 ,2 ]
Shi, Qiucheng [1 ,2 ]
Quan, Jingjing [1 ,2 ]
Li, Xi [3 ]
Yu, Yunsong [1 ,2 ]
机构：
[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Infect Dis, Coll Med, Hangzhou 310016, Zhejiang, Peoples R China
[2] Key Lab Microbial Technol & Bioinformat Zhejiang, Hangzhou, Zhejiang, Peoples R China
[3] Zhejiang Prov Peoples Hosp, Ctr Lab Med, Hangzhou, Zhejiang, Peoples R China
来源：
MICROBIAL DRUG RESISTANCE | 2018年 / 24卷 / 08期
关键词：
Klebsiella pneumoniae; colistin resistance; mgrB; mcr-1; fitness; HETERORESISTANCE; PREVALENCE;
D O I：
10.1089/mdr.2017.0291
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The inactivated mgrB gene and the mcr-1 gene are important mechanisms of colistin resistance in Klebsiella pneumoniae and they are threats to the clinical use of colistin. In this study, mcr-1 gene was cloned into K. pneumoniae strains (XH209 and KP10) and their derived strains (XH209M and KP10M), which showed high-level resistance to colistin. The acquisition of the mcr-1 gene led to colistin resistance in XH209 and KP10, but the addition of mcr-1 gene did not cause change of colistin minimum inhibitory concentrations in the XH209M and KP10M. In addition, the impact of mcr-1 gene on growth rate showed strain specific in K. pneumoniae. In conclusion, the mcr-1 gene does not cause the same level of colistin resistance as the inactivated mgrB gene in K. pneumoniae. The mcr-1 gene has no effect on colisitin resistance when it coexists with inactivated mgrB gene in K. pneumoniae.
引用
收藏
页码：1117 / 1120
页数：4
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