Bisphosphosphonate-calcium phosphate cement composite and its properties

被引：6
|
作者：
Parasaram, Vaideesh [1 ]
Chowdhury, Aniqa [1 ]
Karamched, Saketh R. [1 ]
Siclari, Steven [1 ]
Parrish, Joe [1 ]
Nosoudi, Nasim [1 ,2 ]
机构：
[1] Clemson Univ, Dept Bioengn, Clemson, SC USA
[2] Wright State Univ, Dept Biomed Ind & Human Factors Engn, Dayton, OH 45435 USA
来源：
BIO-MEDICAL MATERIALS AND ENGINEERING | 2019年 / 30卷 / 03期
关键词：
Bisphosphonates; calcium phosphate cement (CPC); drug delivery; bone tissue engineering; BONE CEMENTS; BISPHOSPHONATES; ALENDRONATE; CERAMICS;
D O I：
10.3233/BME-191055
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Calcium phosphate cement (CPC) has been studied extensively due to its bioactivity and biodegradability. CPC is typically made by a combination of multiple calcium phosphates that form a paste that sets and hardens in the body after being combined with either water or an aqueous solution. It is highly moldable and easily manipulated, and CPCs possess osteoconductive properties. Due to these characteristics, CPCs offer great promise in bone grafting applications. CPC combined with drugs has a great potential as drug delivery system and has been studied extensively. In this review we have focused on Bisphosphonate-CPC drug delivery system. In addition, we introduce and discuss the potential of studying other bisphosphonates.
引用
收藏
页码：323 / 331
页数：9
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