Screening for amphetamine and amphetamine-type drugs in doping analysis by liquid chromatography/mass spectrometry

被引：41
|
作者：
Deventer, K [1 ]
Van Eenoo, P [1 ]
Delbeke, FT [1 ]
机构：
[1] Univ Ghent, Dept Clin Chem Microbiol & Immunol, Doping Control Lab, B-9052 Zwijnaarde, Belgium
来源：
RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2006年 / 20卷 / 05期
关键词：
D O I：
10.1002/rcm.2372
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A selective and sensitive method for the qualitative screening of urine samples for 27 amphetamine and amphetamine-type drugs in the field of doping analysis is described. The method consists of a liquid-liquid extraction with diethyl ether at pH 14 and analysis of the extracts with a LCQ-Deca((R)) mass spectrometer equipped with an atmospheric pressure chemical ionisation interface, operated in positive ionisation mode. The total run time was 15 min. All compounds were analysed in MS2 or MS3. The detection limit for all compounds was lower than 25 ng/mL except for chlorphentermine (detection limit: 250 ng/mL). Copyright (c) 2006 John Wiley & Sons, Ltd.
引用
收藏
页码：877 / 882
页数：6
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