Association of interleukin-18 and systemic lupus erythematosus

被引：16
|
作者：
Xu, Wang-Dong [1 ]
Pan, Hai-Feng [1 ]
Ye, Dong-Qing [1 ]
机构：
[1] Anhui Med Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Hefei 230032, Anhui, Peoples R China
来源：
RHEUMATOLOGY INTERNATIONAL | 2013年 / 33卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Interleukin-18; Systemic lupus erythematosus; Therapeutic; NATURAL-KILLER-CELLS; PROMOTER POLYMORPHISMS; DENDRITIC CELLS; IL-18; NEPHRITIS; DISEASE; SERUM; ACTIVATION; MICE;
D O I：
10.1007/s00296-012-2623-x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Interleukin-18 (IL-18), belongs to the IL-1 cytokine family, has a variety of effects on dendritic cell, T cell, natural killer cell. Previous studies have identified that IL-18 was associated with the pathogenesis of systemic lupus erythematosus (SLE), wherein elevated expression of IL-18 was found in the serum of patients, and IL-18 polymorphisms with susceptibility to SLE were reported, suggesting that IL-18 may be therapeutically relevant to SLE. In this article, we will discuss the role of IL-18 in the pathogenesis of and its therapeutic potential in SLE based on current understandings.
引用
收藏
页码：3055 / 3057
页数：3
相关论文
共 50 条
  • [31] Association of interleukin-18 and asthma
    Xu, Ming-Hui
    Yuan, Feng-Lai
    Wang, Shu-Jing
    Xu, Hui-Ying
    Li, Cheng-Wan
    Tong, Xiao
    [J]. INFLAMMATION, 2017, 40 (01) : 324 - 327
  • [32] Association of interleukin-18 and asthma
    Ming-Hui Xu
    Feng-Lai Yuan
    Shu-Jing Wang
    Hui-Ying Xu
    Cheng-Wan Li
    Xiao Tong
    [J]. Inflammation, 2017, 40 : 324 - 327
  • [33] Relationship of plasma interleukin-18 concentrations to traditional and non-traditional cardiovascular risk factors in patients with systemic lupus erythematosus
    Tso, Tim K.
    Huang, Wen-Nan
    Huang, Hui-Yu
    Chang, Chen-Kang
    [J]. RHEUMATOLOGY, 2006, 45 (09) : 1148 - 1153
  • [34] Association of interleukin-10 promoter polymorphisms with systemic lupus erythematosus
    Chong, WP
    Ip, WK
    Lau, CS
    Chan, TM
    Lau, YL
    [J]. GENES AND IMMUNITY, 2004, 5 (06) : 484 - 492
  • [35] Association of interleukin-10 promoter polymorphisms with systemic lupus erythematosus
    W P Chong
    W K Ip
    W H-S Wong
    C S Lau
    T M Chan
    Y L Lau
    [J]. Genes & Immunity, 2004, 5 : 484 - 492
  • [36] Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus
    Sawalha, A. H.
    Kaufman, K. M.
    Kelly, J. A.
    Adler, A. J.
    Aberle, T.
    Kilpatrick, J.
    Wakeland, E. K.
    Li, Q-Z
    Wandstrat, A. E.
    Karp, D. R.
    James, J. A.
    Merrill, J. T.
    Lipsky, P.
    Harley, J. B.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2008, 67 (04) : 458 - 461
  • [37] Interleukin-18 as a Biomarker of Subclinical Lupus Nephritis
    El Bakry, Samah Abdel Rahman
    Alhefny, AbdelAzim Mohamed
    Al-Zifzaf, Dina Shawky
    Nada, Ola Hasan
    El Kabarity, Rania Hamdy
    Omar, Khaled
    [J]. ARCHIVES OF RHEUMATOLOGY, 2015, 30 (01) : 6 - 15
  • [38] Proinflammatory interferon-γ-inducing monokines (interleukin-12, interleukin-18, interieukin-15) -: serum profile in patients with systemic lupus erythematosus
    Robak, E
    Robak, T
    Wozniacka, A
    Zak-Prelich, M
    Sysa-Jedrzejowska, A
    Stepien, H
    [J]. EUROPEAN CYTOKINE NETWORK, 2002, 13 (03) : 364 - 368
  • [39] INTERLEUKIN-18 AS A PREDICTOR OF SUBCLINICAL CARDIOVASCULAR AFFECTION AND DISEASE ACTIVITY IN SYSTEMIC LUPUS PATIENTS
    Tabra, S. A. A.
    Abu-Zaid, M. H.
    Maria, D.
    Elsharaby, R.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2023, 82 : 1542 - 1542
  • [40] Elevated Interleukin-18 Receptor Accessory Protein Mediates Enhancement in Reactive Oxygen Species Production in Neutrophils of Systemic Lupus Erythematosus Patients
    Ma, Jie
    Lam, Ian Kar Yin
    Lau, Chak-Sing
    Chan, Vera Sau Fong
    [J]. CELLS, 2021, 10 (05)
12345