Association of interleukin-18 and systemic lupus erythematosus

被引：16
|
作者：
Xu, Wang-Dong [1 ]
Pan, Hai-Feng [1 ]
Ye, Dong-Qing [1 ]
机构：
[1] Anhui Med Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Hefei 230032, Anhui, Peoples R China
来源：
RHEUMATOLOGY INTERNATIONAL | 2013年 / 33卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Interleukin-18; Systemic lupus erythematosus; Therapeutic; NATURAL-KILLER-CELLS; PROMOTER POLYMORPHISMS; DENDRITIC CELLS; IL-18; NEPHRITIS; DISEASE; SERUM; ACTIVATION; MICE;
D O I：
10.1007/s00296-012-2623-x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Interleukin-18 (IL-18), belongs to the IL-1 cytokine family, has a variety of effects on dendritic cell, T cell, natural killer cell. Previous studies have identified that IL-18 was associated with the pathogenesis of systemic lupus erythematosus (SLE), wherein elevated expression of IL-18 was found in the serum of patients, and IL-18 polymorphisms with susceptibility to SLE were reported, suggesting that IL-18 may be therapeutically relevant to SLE. In this article, we will discuss the role of IL-18 in the pathogenesis of and its therapeutic potential in SLE based on current understandings.
引用
收藏
页码：3055 / 3057
页数：3
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