Copper-Catalyzed Trifluoromethylation-Cyclization of Enynes: Highly Regioselective Construction of Trifluoromethylated Carbocycles and Heterocycles

被引：71

作者：

Gao, Pin ^{[1
]}

Yan, Xiao-Biao ^{[1
]}

Tao, Tao ^{[1
]}

Yang, Fan ^{[1
]}

He, Ting ^{[1
]}

Song, Xian-Rong ^{[1
]}

Liu, Xue-Yuan ^{[1
]}

Liang, Yong-Min ^{[1
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 43期

基金：

美国国家科学基金会;

关键词：

copper; cyclization; enynes; regioselectivity; trifluoromethylation; ENANTIOSELECTIVE ALPHA-TRIFLUOROMETHYLATION; PD(II)-CATALYZED ORTHO-TRIFLUOROMETHYLATION; SILVER-MEDIATED TRIFLUOROMETHYLATION; BOND-FORMATION; ELECTROPHILIC TRIFLUOROMETHYLATION; OXIDATIVE TRIFLUOROMETHYLATION; REDUCTIVE ELIMINATION; TERMINAL ALKENES; ARYL IODIDES; ARENES;

D O I：

10.1002/chem.201303025

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Regioselective trifluoromethylation-cyclization: A method for copper-catalyzed trifluoromethylation-cyclization of simple enynes using the C-C triple bond as a nucleophile is reported for the first time (see scheme). The reaction proceeds efficiently in a highly regioselective manner to give various 5- or 6-exo-dig carbocycles and heterocycles in moderate to high yields.

引用

页码：14420 / 14424

页数：5

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