Induced Pluripotent Stem Cells as a Disease Modeling and Drug Screening Platform

被引：136
|
作者：
Ebert, Antje D. [1 ,2 ,3 ]
Liang, Ping [1 ,2 ,3 ]
Wu, Joseph C. [1 ,2 ,3 ,4 ]
机构：
[1] Stanford Univ, Dept Med, Div Cardiol, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Radiol, MIPS, Stanford, CA 94305 USA
[3] Stanford Univ, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA
[4] Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA
来源：
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 2012年 / 60卷 / 04期
关键词：
induced pluripotent stem cells; disease modeling; cardiovascular disease; drug screening; high-throughput screening; LONG QT SYNDROME; TORSADE-DE-POINTES; HERG POTASSIUM CHANNEL; HUMAN SOMATIC-CELLS; INTERVAL PROLONGATION; IPS CELLS; EFFICIENT GENERATION; CARDIAC-ARRHYTHMIA; CARDIOMYOCYTES; FIBROBLASTS;
D O I：
10.1097/FJC.0b013e318247f642
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Induced pluripotent stem cells (iPSCs) hold great hopes for therapeutic application in various diseases. Although ongoing research is dedicated to achieving clinical translation of iPSCs, further understanding of the mechanisms that underlie complex pathogenic conditions is required. Compared with other classical models for studying diseases, iPSCs provide considerable advantages. A newly emerging application of iPSCs is in vitro disease modeling, which can significantly improve the never-ending search for new pharmacological cures. Here, we will discuss current efforts to create iPSC-dependent patient-specific disease models. Furthermore, we will review the use of iPSCs for development and testing of new therapeutic agents and the implications for high-throughput drug screening.
引用
收藏
页码：408 / 416
页数：9
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