Alkylation Reactions of Azodicarboxylate Esters with 4-Alkyl-1,4-Dihydropyridines under Catalyst-Free Conditions

被引：30

作者：

Nakajima, Kazunari ^{[1
]}

Zhang, Yulin ^{[2
]}

Nishibayashi, Yoshiaki ^{[2
]}

机构：

[1] Univ Tokyo, Sch Engn, Frontier Res Ctr Energy & Resources, Bunkyo Ku, Tokyo 1138656, Japan

[2] Univ Tokyo, Sch Engn, Dept Syst Innovat, Bunkyo Ku, Tokyo 1138656, Japan

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 12期

关键词：

D O I：

10.1021/acs.orglett.9b01537

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Introduction of alkyl groups on azodicarboxylate esters is an important method to prepare alkyl amine derivatives. Herein, we report reactions of 4-alkyl-1,4-dihydropyridines as alkylation reagents with di-tert-butyl azodicarboxylate to prepare alkyl amine derivatives under heating conditions. The alkylation reactions via C-C bond cleavage of the dihydropyridines are achieved in the absence of catalysts and additives.

引用

页码：4642 / 4645

页数：4

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