Two Novel Anti-Inflammatory 21-Nordammarane Saponins from Tetraploid Jiaogulan (Gynostemma pentaphyllum)

被引：42

作者：

Yang, Fei ^{[1
]}

Shi, Haiming ^{[1
]}

Zhang, Xiaowei ^{[1
]}

Yu, Liangli ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Agr & Biol, SJTU Rich Res Inst, Inst Food & Nutraceut Sci, Shanghai 200240, Peoples R China

[2] Univ Maryland, Dept Nutr & Food Sci, College Pk, MD 20742 USA

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2013年 / 61卷 / 51期

基金：

国家高技术研究发展计划(863计划);

关键词：

Gynostemma pentaphyllum; 21-nordammarane saponins; anti-inflammation; NMR; structure identification; THUNB; MAKINO; CONSTITUENTS; FLAVONOIDS; GLYCOSIDES; GYPENOSIDE;

D O I：

10.1021/jf404726z

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Two novel 20-oxo-21-nordammar-22, 24-diene saponins, 21-norgypenosides A (1) and B (2), were characterized from the aerial parts of tetraploid Jiaogulan (Gynostemma pentaphyllum), a popular tea ingredient. Their structures, including the absolute configurations, were comprehensively elucidated by HRESIMS, 1D and 2D NMR data, chemical degradation, and through comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. The two compounds suppressed the expression of interleukin (IL)-1 beta, cyclooxygenase (COX)-2, and tumor necrosis factor (TNF)-alpha mRNAs in the lipopolysaccharide-induced RAW 264.7 mouse macrophage cells at 10 and 100 mu g/mL, suggesting their potential anti-inflammatory effects.

引用

页码：12646 / 12652

页数：7

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