In-vitro evaluation of the pharmaceutical quality of some ibuprofen tablets dispensed in Nigeria

The purpose of this study was to determine the pharmaceutical quality of some Ibuprofen tablets dispensed in Nigerian. 19 different brands of Ibuprofen tablets were purchased from pharmacies and open markets in 3 states in Nigeria. The organoleptic and physicochemical properties of these Ibuprofen tablets were assessed according to British Pharmacopoeia (BP), and unofficial standards as recommended by the manufacturers. Of the 19 brands of tablets assessed, 12 brands passed the uniformity of content test while 15 brands passed the disintegration test and only four brands passed the dissolution test. Ibuprofen tablets dispensed in Nigeria varied considerably in their pharmaceutical quality. A strict check of the quality of brands of Ibuprofen by regulatory agencies and distributors before they are dispensed to the public is therefore recommended.