Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans

被引:546
|
作者
Bailey, Stephen J. [1 ]
Winyard, Paul [2 ]
Vanhatalo, Anni [1 ]
Blackwell, Jamie R. [1 ]
DiMenna, Fred J. [1 ]
Wilkerson, Daryl P. [1 ]
Tarr, Joanna [2 ]
Benjamin, Nigel [2 ]
Jones, Andrew M. [1 ]
机构
[1] Univ Exeter, Sch Sport & Hlth Sci, Exeter EX1 2LU, Devon, England
[2] Univ Exeter, Peninsula Coll Med & Dent, Exeter EX1 2LU, Devon, England
关键词
exercise economy; muscle efficiency; O-2; uptake; exercise performance; fatigue; NITRIC-OXIDE SYNTHASE; OXYGEN-UPTAKE KINETICS; GAS-EXCHANGE KINETICS; HUMAN SKELETAL-MUSCLE; CYTOCHROME-C-OXIDASE; L-NAME; MITOCHONDRIAL BIOGENESIS; CYCLE EXERCISE; PLASMA NITRITE; DYNAMICS;
D O I
10.1152/japplphysiol.00722.2009
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Bailey SJ, Winyard P, Vanhatalo A, Blackwell JR, DiMenna FJ, Wilkerson DP, Tarr J, Benjamin N, Jones AM. Dietary nitrate supplementation reduces the O-2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J Appl Physiol 107: 1144-1155, 2009. First published August 6, 2009; doi:10.1152/japplphysiol.00722.2009.-Pharmacological sodium nitrate supplementation has been reported to reduce the O-2 cost of submaximal exercise in humans. In this study, we hypothesized that dietary supplementation with inorganic nitrate in the form of beetroot juice (BR) would reduce the O-2 cost of submaximal exercise and enhance the tolerance to high-intensity exercise. In a double-blind, placebo (PL)-controlled, crossover study, eight men (aged 19-38 yr) consumed 500 ml/day of either BR (containing 11.2 +/- 0.6 mM of nitrate) or blackcurrant cordial (as a PL, with negligible nitrate content) for 6 consecutive days and completed a series of "step" moderate-intensity and severe-intensity exercise tests on the last 3 days. On days 4-6, plasma nitrite concentration was significantly greater following dietary nitrate supplementation compared with PL (BR: 273 +/- 44 vs. PL: 140 +/- 50 nM; P < 0.05), and systolic blood pressure was significantly reduced (BR: 124 +/- 2 vs. PL: 132 +/- 5 mmHg; P < 0.01). During moderate exercise, nitrate supplementation reduced muscle fractional O-2 extraction (as estimated using near-infrared spectroscopy). The gain of the increase in pulmonary O-2 uptake following the onset of moderate exercise was reduced by 19% in the BR condition (BR: 8.6 +/- 0.7 vs. PL: 10.8 +/- 1.6 ml.min(-1).W-1; P < 0.05). During severe exercise, the O-2 uptake slow component was reduced (BR: 0.57 +/- 0.20 vs. PL: 0.74 +/- 0.24 l/min; P < 0.05), and the time-to-exhaustion was extended (BR: 675 +/- 203 vs. PL: 583 +/- 145 s; P < 0.05). The reduced O-2 cost of exercise following increased dietary nitrate intake has important implications for our understanding of the factors that regulate mitochondrial respiration and muscle contractile energetics in humans.
引用
收藏
页码:1144 / 1155
页数:12
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