Regulatory pathways involved in the infection-induced production of IFN-γ by NK cells

被引：68
|
作者：
Lieberman, LA [1 ]
Hunter, CA [1 ]
机构：
[1] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA
来源：
MICROBES AND INFECTION | 2002年 / 4卷 / 15期
基金：
美国国家卫生研究院;
关键词：
NK cell; IFN-gamma; pathogen; infection; Stat4; IL-12; innate immunity;
D O I：
10.1016/S1286-4579(02)00036-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The production of interferon gamma (IFN-gamma) by natural killer (NK) cells provides an innate mechanism of resistance to many intracellular pathogens. These events are regulated by multiple cytokines and transcription factors which have both positive and negative effects. This article reviews the role of cytokines, as well as costimulatory and signaling pathways, involved in NK cell responses associated with resistance to infection. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码：1531 / 1538
页数：8
相关论文
共 50 条
  • [41] Interleukin-37 exacerbates liver inflammation and promotes IFN-γ production in NK cells
    Lin, Chia-, I
    Wang, Yu-Wen
    Su, Kang-Yi
    Chuang, Ya-Hui
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2024, 142
  • [42] A disturbed interaction with accessory cells upon opportunistic infection with Pseudomonas aeruginosa contributes to an impaired IFN-γ production of NK cells in the lung during sepsis-induced immunosuppression
    Pastille, Eva
    Pohlmann, Stephanie
    Wirsdoerfer, Florian
    Reib, Anna
    Flohe, Stefanie B.
    INNATE IMMUNITY, 2015, 21 (02) : 115 - 126
  • [43] Respiratory syncytial virus infection suppresses IFN-γ production of γδ T cells
    Aoyagi, M
    Shimojo, N
    Sekine, K
    Nishimuta, T
    Kohno, Y
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2003, 131 (02): : 312 - 317
  • [44] NK cells recruited to liver allografts are a source of IFN-γ.
    Obara, H
    Martinez, OM
    Ogura, Y
    Hsieh, CL
    Esquivel, CO
    Krams, SM
    AMERICAN JOURNAL OF TRANSPLANTATION, 2004, 4 : 249 - 249
  • [45] Differential regulation of IFN-γ gene expression by IFN-α and IL-12 in human NK cells
    Sareneya, T
    Paananen, A
    Miettinen, M
    Timonen, T
    Julkunen, I
    Matikainen, S
    FASEB JOURNAL, 2002, 16 (05): : A1084 - A1084
  • [46] Interleukin-12 activates NK cells for IFN-γ -dependent and NKT cells for IFN-γ -independent antimetastatic activity
    Hafner, M
    Falk, W
    Echtenacher, B
    Männel, DN
    EUROPEAN CYTOKINE NETWORK, 1999, 10 (04) : 541 - 548
  • [47] Requirement of IFN-γ production by non-T, non-NK cells for resistance against reactivation of Toxoplasma infection in the brain
    Suzuki, Y
    Kang, H
    FASEB JOURNAL, 2001, 15 (04): : A688 - A688
  • [48] HMGB1 Is Involved in IFN-α Production and TRAIL Expression by HIV-1-Exposed Plasmacytoid Dendritic Cells: Impact of the Crosstalk with NK Cells
    Saidi, Hela
    Bras, Marlene
    Formaglio, Pauline
    Melki, Marie-Therese
    Charbit, Bruno
    Herbeuval, Jean-Philippe
    Gougeon, Marie-Lise
    PLOS PATHOGENS, 2016, 12 (02)
  • [49] Reduction of regulatory T cells during acute Toxoplasma gondii infection is caused by IFN-γ
    Olguin, Jonadab
    Fernandez, Jacquelina
    Salinas, Nohemi
    Terrazas, Luis
    Saavedra, Rafael
    JOURNAL OF IMMUNOLOGY, 2015, 194
  • [50] Soy isoflavones and their metabolites modulate IL-12-induced NK cell IFN-γ production
    Mace, Thomas A.
    King, Samantha
    Farren, Matthew
    McMichael, Elizabeth
    Scoville, Steven
    Carson, William E.
    Young, Gregory
    Thomas-Ahner, Jennifer
    Riedl, Kenneth M.
    Schwartz, Steven
    Clinton, Steven K.
    Lesinski, Gregory
    CANCER RESEARCH, 2015, 75
12345