Macrophage polarization by phytotherapy in the tumor microenvironment

被引：13

作者：

Saeedifar, Amir Mohammad ^{[1
]}

Mosayebi, Ghasem ^{[1
,2
]}

Ghazavi, Ali ^{[1
,3
]}

Bushehri, Rouhollah Hemmati ^{[1
]}

Ganji, Ali ^{[1
,2
]}

机构：

[1] Arak Univ Med Sci, Sch Med, Dept Immunol & Microbiol, Arak, Iran

[2] Arak Univ Med Sci, Mol & Med Res Ctr, Arak, Iran

[3] Arak Univ Med Sci, Tradit & Complementary Med Res Ctr TCMRC, Arak, Iran

来源：

PHYTOTHERAPY RESEARCH | 2021年 / 35卷 / 07期

关键词：

macrophage polarization; phytotherapy; signaling pathways; tumor; GLIOBLASTOMA CELL-PROLIFERATION; MOLECULAR-MECHANISMS; SIGNAL TRANSDUCER; CHLOROGENIC ACID; DENDRITIC CELLS; OVARIAN-CANCER; M2; PHENOTYPE; BETA-ELEMENE; IN-VITRO; KAPPA-B;

D O I：

10.1002/ptr.7058

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several signaling pathways were involved in M1 (classic) and M2 (alternative) macrophage polarization. Disruption of M2-related signaling pathways and improvement of M1-related signaling pathways can be identified as one of the cancer therapeutic approaches. Prevention of macrophage differentiation into M2 by different herbal agents with antitumor properties can be considered as a promising therapeutic target for cancer patients. In the present review study, we investigated the effect of herbal compounds on M1 and M2 related signaling pathways to reduce M2 and increase M1 macrophage polarization for the treatment of different types of cancer.

引用

页码：3632 / 3648

页数：17

共 50 条

[41] Redefining Tumor-Associated Macrophage Subpopulations and Functions in the Tumor Microenvironment
Wu, Kaiyue
Lin, Kangjia
Li, Xiaoyan
Yuan, Xiangliang
Xu, Peiqing
Ni, Peihua
Xu, Dakang
FRONTIERS IN IMMUNOLOGY, 2020, 11 : 1731
[42] Metabolic Cancer-Macrophage Crosstalk in the Tumor Microenvironment
de Goede, Kyra E.
Driessen, Amber J. M.
van den Bossche, Jan
BIOLOGY-BASEL, 2020, 9 (11): : 1 - 17
[43] ROLE OF MACROPHAGE IN TUMOR MICROENVIRONMENT: PROSPECT IN CANCER IMMUNOTHERAPY
Gautam, P. K.
Deepak, P.
Kumar, S.
Acharya, A.
EUROPEAN JOURNAL OF INFLAMMATION, 2013, 11 (01) : 1 - 14
[44] Macrophage barrier in the tumor microenvironment and potential clinical applications
Ji, Shuai
Shi, Yuqing
Yin, Bo
CELL COMMUNICATION AND SIGNALING, 2024, 22 (01)
[45] How does the tumor microenvironment affect macrophage aggressiveness
Weagel, Evita G.
Liu, Ping Guo
Meng, Wei
Smith, Curren D.
Robison, Richard A.
O'Neill, Kim L.
CANCER RESEARCH, 2014, 74 (19)
[46] Macrophage barrier in the tumor microenvironment and potential clinical applications
Shuai Ji
Yuqing Shi
Bo Yin
Cell Communication and Signaling, 22
[47] Trabectedin modulates macrophage polarization in the tumor-microenvironment. Role of KV1.3 and KV1.5 channels
Peraza, Diego A.
Povo-Retana, Adrian
Mojena, Marina
Garcia-Redondo, Ana B.
Aviles, Pablo
Bosca, Lisardo
Valenzuela, Carmen
BIOMEDICINE & PHARMACOTHERAPY, 2023, 161
[48] Tramadol suppresses growth of orthotopic liver tumors via promoting M1 macrophage polarization in the tumor microenvironment
Wang, Lei
Guo, Weijia
Guan, Hongman
Yan, Ni
Cai, Xiaolan
Zhu, Lili
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2024, 397 (06) : 4205 - 4218
[49] Molecular profiling of the tumor microenvironment in glioblastoma patients: correlation of microglia/macrophage polarization state with metalloprotease expression profiles and survival
Gjorgjevski, Marko
Hannen, Ricarda
Carl, Barbara
Li, Yu
Landmann, Emilie
Buchholz, Malte
Bartsch, Joerg W.
Nimsky, Christopher
BIOSCIENCE REPORTS, 2019, 39
[50] ANXA1 Contained in EVs Regulates Macrophage Polarization in Tumor Microenvironment and Promotes Pancreatic Cancer Progression and Metastasis
Novizio, Nunzia
Belvedere, Raffaella
Pessolano, Emanuela
Morello, Silvana
Tosco, Alessandra
Campiglia, Pietro
Filippelli, Amelia
Petrella, Antonello
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (20)

← 1 2 3 4 5 →