Characterization of chromosome changes in two human prostatic carcinoma cell lines (PC-3 and DU145) using chromosome painting and comparative genomic hybridization

被引：23
|
作者：
Bernardino, J [1 ]
Bourgeois, CA [1 ]
Muleris, M [1 ]
Dutrillaux, AM [1 ]
Malfoy, B [1 ]
Dutrillaux, B [1 ]
机构：
[1] NATL CTR SCI RES,DEPT MOL CYTOGENET,PARIS,FRANCE
来源：
CANCER GENETICS AND CYTOGENETICS | 1997年 / 96卷 / 02期
关键词：
D O I：
10.1016/S0165-4608(96)00258-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Using chromosome painting, a study of chromosomal abnormalities has been performed in two prostatic carcinoma cell lines, PC-3 and DU145. In PC-3, this analysis revealed a highly rearranged hypotriploid karyotype with 54 to 61 chromosomes and numerous rearrangements of chromosomes 1, 3, 5, 8, 10, and 14. At passage 73, DU145 had a hypotriploid karyotype with few rearrangements of chromosomes 1, 3, 5, 12, 13, and 20, whereas at passage 153, this cell line showed a near-tetraploid karyotype with a great number of rearrangements involving chromosomes 3, 6, 8, 20, 12, and 17. A single rearrangement was shared by the 2 cell lines, an i(5)(p10). A comparative genomic hybridization study demonstrated a noticeable amplification of bands 10q22.3-q23 and 14q22-q24 in the PC-3 cell line. No amplification signal was detected for DU145. (C) Elsevier Science Inc., 1997.
引用
收藏
页码：123 / 128
页数：6
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