Differential exhaustion on cytokine release (DECREASE) by ERY974, a novel T-cell-redirecting antibody targeting glypican-3: A new type of T-cell exhaustion

被引：0
|
作者：
Hoshino, Mayumi [1 ]
Sano, Yuji [1 ]
Kinoshita, Yasuko [1 ]
Azuma, Yumiko [1 ]
Tsunenari, Toshiaki [1 ]
Kayukawa, Yoko [1 ]
Noguchi, Mizuho [1 ]
Ishiguro, Takahiro [1 ]
Kishishita, Shohei [1 ]
Sawada, Noriaki [1 ]
Endo, Mika [1 ]
Nezu, Junichi [1 ]
机构：
[1] Chugai Pharmaceut Co Ltd, Tokyo, Japan
来源：
CANCER RESEARCH | 2019年 / 79卷 / 13期
关键词：
D O I：
10.1158/1538-7445.AM2019-2378
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
2378
引用
收藏
页数：2
相关论文
共 50 条
  • [31] Exploring T-cell exhaustion features in Acute myocardial infarction for a Novel Diagnostic model and new therapeutic targets by bio-informatics and machine learning
    Jin, Nake
    Rong, Jiacheng
    Chen, Xudong
    Huang, Lei
    Ma, Hong
    BMC CARDIOVASCULAR DISORDERS, 2024, 24 (01):
  • [32] miR-149-3p reverses CD8+ T-cell exhaustion by reducing inhibitory receptors and promoting cytokine secretion in breast cancer cells
    Zhang, Meng
    Gao, Dian
    Shi, Yanmei
    Wang, Yifan
    Joshi, Rakesh
    Yu, Qiongfang
    Liu, Daheng
    Alotaibi, Faizah
    Zhang, Yujuan
    Wang, Hongmei
    Li, Qing
    Zhang, Zhu-Xu
    Koropatnick, James
    Min, Weiping
    OPEN BIOLOGY, 2019, 9 (10) : 190061
  • [33] Targeting sphingosine 1-phosphate receptor 3 inhibits T-cell exhaustion and regulates recruitment of proinflammatory macrophages to improve antitumor efficacy of CAR-T cells against solid tumor
    Gao, Ge
    Liao, Weiting
    Shu, Pei
    Ma, Qizhi
    He, Xia
    Zhang, Benxia
    Qin, Diyuan
    Wang, Yongsheng
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2023, 11 (08)
  • [34] Effect of modulation of CD3 binding in a PSMAxCD3 T-cell engaging bispecific antibody on maintenance of efficient tumor cell kill and cytokine release.
    Buelow, Ben
    Dang, Kevin
    Dalvi, Pranjali
    Li, Yuping
    Cheung, Alexander
    Rancan, Chiara
    Sankaran, Preethi
    Duy Pham
    Harris, Katherine
    Davison, Laura
    Balasubramani, Aarti
    Clarke, Starlynn
    Starzinski, Alec
    Fong, Lawrence
    Iyer, Suhasini
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [35] Decrease of T-cells exhaustion markers programmed cell death-1 and T-cell immunoglobulin and mucin domain-containing protein 3 and plasma IL-10 levels after successful treatment of chronic hepatitis C
    Sylwia Osuch
    Tomasz Laskus
    Hanna Berak
    Karol Perlejewski
    Karin J. Metzner
    Marcin Paciorek
    Marek Radkowski
    Kamila Caraballo Cortés
    Scientific Reports, 10
  • [36] Decrease of T-cells exhaustion markers programmed cell death-1 and T-cell immunoglobulin and mucin domain-containing protein 3 and plasma IL-10 levels after successful treatment of chronic hepatitis C
    Osuch, Sylwia
    Laskus, Tomasz
    Berak, Hanna
    Perlejewski, Karol
    Metzner, Karin J.
    Paciorek, Marcin
    Radkowski, Marek
    Cortes, Kamila Caraballo
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [37] A CD3 x FRα T-cell engaging bispecific antibody for efficient killing of ovarian cancer cells with minimal cytokine release.
    Buelow, Ben
    Avanzino, Brian
    Balasubramani, Aarti
    Boudreau, Andrew
    Davison, Laura
    Ganesan, Priya
    Harris, Katherine
    Hartstein, Sharon
    Malik-Chaudhry, Harbani
    Pham, Duy
    Prabhakar, Kirthana
    Rangaswamy, Udaya
    Saiganesh, Sowmya
    Schellenberger, Ute
    Ugamraj, Harshad
    Kehm, Hannes
    Trinklein, Nathan
    Iyer, Suhasini
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [38] Targeting Multiple Myeloma with AMG 424, a Novel Anti-CD38/CD3 Bispecific T-cell-recruiting Antibody Optimized for Cytotoxicity and Cytokine Release
    de Zafra, Christina L. Zuch
    Fajardo, Flordeliza
    Zhong, Wendy
    Bernett, Matthew J.
    Muchhal, Umesh S.
    Moore, Gregory L.
    Stevens, Jennitte
    Case, Ryan
    Pearson, Joshua T.
    Liu, Siyuan
    McElroy, Patricia L.
    Canon, Jude
    Desjarlais, John R.
    Coxon, Angela
    Balazs, Mercedesz
    Nolan-Stevaux, Olivier
    CLINICAL CANCER RESEARCH, 2019, 25 (13) : 3921 - 3933
  • [39] A Novel T-Cell Redirecting Anti-CD19-F(ab)2/CD3scFv Bispecific Antibody Exhibits Potent Lymphoma Cytotoxicity
    Rossi, Diane L.
    Rossi, Edmund A.
    Cardillo, Thomas M.
    Goldenberg, David M.
    Chang, Chien-Hsing
    BLOOD, 2012, 120 (21)
  • [40] Characterization of JNJ-80948543, a Novel CD79bxCD20xCD3 Trispecific T-Cell Redirecting Antibody for the Treatment of B-Cell Non-Hodgkin Lymphoma
    Kuchnio, Anna
    Yang, Danlin
    Vloemans, Nele
    Lowenstein, Cassandra
    Cornelissen, Ivo
    Amorim, Ricardo
    Han, Chao
    Sukumaran, Siddharth
    Janssen, Lut
    Suls, Toon
    Bekkers, Mariette
    Lasorsa, Elena
    Fontana, Lorena
    Medeiros, Nicole
    Wu, Bingyuan
    Chen, Jun
    Feldkamp, Michael
    Wu, Sheng-Jiun
    Habte, Habtom
    Krayer, John
    Holland, Cam
    Deyoung, M. Phillip
    Elsayed, Yusri A.
    Philippar, Ulrike
    BLOOD, 2022, 140 : 3105 - 3106
12345