Jaspines A and B:: two new cytotoxic sphingosine derivatives from the marine sponge Jaspis sp.

被引：124
|
作者：
Ledroit, V
Debitus, C
Lavaud, C
Massiot, G
机构：
[1] CNRS, CRSN, Inst Rech & Dev, F-31527 Ramonville St Agne, France
[2] CNRS, UMR 6013, Lab Pharmacognosie, CPCBAI, F-61097 Reims 2, France
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 02期
关键词：
D O I：
10.1016/S0040-4039(02)02541-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The ethanolic extract of the sponge Jaspis sp. collected in Vanuatu showed cytotoxicity against KB tumour cells (IC95 = 10 mug/ml). A bioassay-guided fractionation led to the isolation of two new cytotoxic sphingosine derivatives, jaspine A and jaspine B. Structures were elucidated by spectroscopic methods, and absolute configuration by chemical derivatisation. The cytotoxicity of jaspine B hydrochloride was evaluated against the A549 lung tumour cell line (IC50 = 3.4 x 10(-7) M). (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：225 / 228
页数：4
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