STAT pathway in the regulation of zoledronic acid-induced apoptosis in chronic myeloid leukemia cells

被引：12
|
作者：
Kiper, Hatice Demet [1 ]
Kaymaz, Burcin Tezcanli [2 ]
Gokbulut, Aysun Adan [3 ]
Selvi, Nur [2 ]
Avci, Cigir Biray [2 ]
Kosova, Buket [2 ]
Iskender, Guniz [3 ]
Yandim, Melis Kartal [3 ]
Gunduz, Cumhur [2 ]
Sahin, Fahri [4 ]
Baran, Yusuf [3 ]
Saydam, Guray [4 ]
机构：
[1] Ege Univ, Sch Med, Dept Internal Med, Izmir, Turkey
[2] Ege Univ, Sch Med, Dept Med Biol, Izmir, Turkey
[3] Izmir Inst Technol, Sch Sci, Dept Mol Biol & Genet, TR-35430 Izmir, Turkey
[4] Ege Univ, Sch Med, Dept Hematol, Izmir, Turkey
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2013年 / 67卷 / 06期
关键词：
Chronic myeloid leukemia; Zoledronic acid; STATs; ANTITUMOR-ACTIVITY; BREAST-CANCER; 3RD-GENERATION BISPHOSPHONATE; CONSTITUTIVE ACTIVATION; SIGNAL TRANSDUCER; CHRONIC-PHASE; RESISTANCE; INHIBITOR; PAMIDRONATE; INTERFERON;
D O I：
10.1016/j.biopha.2013.04.006
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In this study, we aimed to evaluate the cytotoxic and apoptotic effects of zoledronic acid on K562 chronic myeloid leukemia (CML) cells and to examine the roles of STAT genes on zoledronic acid-induced apoptosis. The results showed that zoledronic acid decreased proliferation, and induced apoptosis in K562 cells in a dose- and time-dependent manner. mRNA and protein levels of STAT3, -5A and -5B genes were significantly reduced in zoledronic acid-treated K562 cells. These data indicated that STAT inhibition by zoledronic acid may be therapeutic in CML patients following the confirmation with clinical studies. (C) 2013 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：527 / 532
页数：6
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