Determination of domperidone in human serum and human breast milk by high-performance liquid chromatography-electrospray mass spectrometry

被引：35
|
作者：
Zavitsanos, AP
MacDonald, C
Bassoo, E
Gopaul, D
机构：
[1] Hewlett Packard Canada Ltd, Chem Anal Div, Mississauga, ON L4W 5G1, Canada
[2] St Josephs Hlth Ctr, Reference Testing Ctr, London, ON N6A 4V2, Canada
来源：
JOURNAL OF CHROMATOGRAPHY B | 1999年 / 730卷 / 01期
关键词：
domperidone;
D O I：
10.1016/S0378-4347(99)00163-2
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A sensitive and selective method for the determination of domperidone in human breast milk and serum has been developed. The same method may be successfully applied to both matrices to a lower limit of quantitation of 0.5 ng/ml. Samples are processed by a liquid-liquid extraction, and analyzed by LC-ESI-MS in positive ion mode. There was no interference, on the domperidone quantitation, from over 30 drugs. Samples from patients, at various times post-dose, were analyzed and a large number showed significant levels of domperidone in the breast milk as well as in the serum. (C) 1999 Elsevier Science B.V. All rights reserved.
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页码：9 / 24
页数：16
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