Macrophage dynamics in diabetic wound healing

被引：35
|
作者：
Waugh, HV [1 ]
Sherratt, JA [1 ]
机构：
[1] Heriot Watt Univ, Sch Math & Comp, Edinburgh EH14 4AS, Midlothian, Scotland
来源：
BULLETIN OF MATHEMATICAL BIOLOGY | 2006年 / 68卷 / 01期
基金：
英国工程与自然科学研究理事会;
关键词：
macrophages; wound healing; diabetes;
D O I：
10.1007/s11538-005-9022-3
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Wound healing in diabetes is a complex process, characterised by a chronic inflammation phase. The exact mechanism by which this occurs is not fully understood, and whilst several treatments for healing diabetic wounds exist, very little research has been conducted towards the causes of the extended inflammation phase. We describe a mathematical model which offers a possible explanation for diabetic wound healing in terms of the distribution of macrophage phenotypes being altered in the diabetic patient compared to normal wound repair. As a consequence of this, we put forward a suggestion for treatment based on rectifying the macrophage phenotype imbalance.
引用
收藏
页码：197 / 207
页数：11
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