Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors

被引：16

作者：

Carlos Lara, Pedro ^{[1
,2
]}

Lloret, Marta ^{[1
,2
]}

Clavo, Bernardino ^{[1
,2
]}

Apolinario, Rosa Maria ^{[2
]}

Bordon, Elisa ^{[2
]}

Rey, Agustin ^{[1
,2
]}

Falcon, Orlando ^{[2
,3
]}

Alonso, Ana Ruiz ^{[1
,2
]}

Belka, Claus ^{[4
]}

机构：

[1] Hosp Univ Dr Negrin, Las Palmas Gran Canaria 35010, Spain

[2] Inst Canario Invest Canc, Canary Isl, Spain

[3] Hosp Univ Materno Infantil, Las Palmas Gran Canaria, Spain

[4] Univ Munich, D-80539 Munich, Germany

来源：

RADIOTHERAPY AND ONCOLOGY | 2008年 / 89卷 / 02期

关键词：

Hypoxia; NHEJ repair; Ku70/80; p53; angiogenesis; Cervical cancer;

D O I：

10.1016/j.radonc.2008.07.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hypoxia may inhibits the NHEJ DNA repair through downregulating Ku70/80 expression and combined with an increased angiogenesis and altered p53 expression would be responsible for tumor progression in cervical carcinoma. (c) 2008 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 89 (2008) 222-226.

引用

页码：222 / 226

页数：5

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