Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors

被引：16
|
作者：
Carlos Lara, Pedro [1 ,2 ]
Lloret, Marta [1 ,2 ]
Clavo, Bernardino [1 ,2 ]
Apolinario, Rosa Maria [2 ]
Bordon, Elisa [2 ]
Rey, Agustin [1 ,2 ]
Falcon, Orlando [2 ,3 ]
Alonso, Ana Ruiz [1 ,2 ]
Belka, Claus [4 ]
机构：
[1] Hosp Univ Dr Negrin, Las Palmas Gran Canaria 35010, Spain
[2] Inst Canario Invest Canc, Canary Isl, Spain
[3] Hosp Univ Materno Infantil, Las Palmas Gran Canaria, Spain
[4] Univ Munich, D-80539 Munich, Germany
来源：
RADIOTHERAPY AND ONCOLOGY | 2008年 / 89卷 / 02期
关键词：
Hypoxia; NHEJ repair; Ku70/80; p53; angiogenesis; Cervical cancer;
D O I：
10.1016/j.radonc.2008.07.018
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hypoxia may inhibits the NHEJ DNA repair through downregulating Ku70/80 expression and combined with an increased angiogenesis and altered p53 expression would be responsible for tumor progression in cervical carcinoma. (c) 2008 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 89 (2008) 222-226.
引用
收藏
页码：222 / 226
页数：5
相关论文
共 50 条
  • [1] Niclosamide sensitizes nasopharyngeal carcinoma to radiation by downregulating Ku70/80 expression
    Li, Jingjing
    Li, Haiwen
    Zhan, Dechao
    Xiang, Mei
    Yang, Jun
    Zuo, Yufang
    Yu, Yin
    Zhou, Hechao
    Jiang, Danxian
    Luo, Haiqing
    Chen, Zihong
    Yu, Zhonghua
    Xu, Zumin
    JOURNAL OF CANCER, 2018, 9 (04): : 736 - 744
  • [2] Expression and chromosome location of hamster Ku70 and Ku80
    Koike, M
    Kuroiwa, A
    Koike, A
    Shiomi, T
    Matsuda, Y
    CYTOGENETICS AND CELL GENETICS, 2001, 93 (1-2): : 52 - 56
  • [3] Expression of Ku70 correlates with survival in carcinoma of the cervix
    Wilson, CR
    Davidson, SE
    Margison, GP
    Jackson, SP
    Hendry, JH
    West, CML
    BRITISH JOURNAL OF CANCER, 2000, 83 (12) : 1702 - 1706
  • [4] The Multifaceted Roles of Ku70/80
    Zahid, Sayma
    Seif El Dahan, Murielle
    Iehl, Florence
    Fernandez-Varela, Paloma
    Le Du, Marie-Helene
    Ropars, Virginie
    Charbonnier, Jean Baptiste
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (08)
  • [5] The Significance of Ku70 Expression in Patients with Nasopharyngeal Carcinoma
    Song, Si Yeol
    Lee, Sang Wook
    Yu, Eunsil
    Cho, Kyung Ja
    Park, Jin Hong
    Kim, Sang Yoon
    Nam, Soon Yuhl
    Lee, Bong Jae
    Kim, Sung Bae
    Choi, Seung Ho
    Do Ahn, Seung
    Shin, Seong Soo
    Choi, Eun Kyung
    Kim, Jong Hoon
    RADIATION ONCOLOGY JOURNAL, 2005, 23 (01): : 1 - 8
  • [6] Expression of Ku70 correlates with survival in carcinoma of the cervix
    C R Wilson
    S E Davidson
    G P Margison
    S P Jackson
    J H Hendry
    C M L West
    British Journal of Cancer, 2000, 83 : 1702 - 1706
  • [7] Decreased expression of Ku70/Ku80 proteins in malignant melanomas of the oral cavity
    Korabiowska, M
    Tscherny, M
    Grohmann, U
    Hönig, JF
    Bartkowski, SB
    Cordon-Cardo, C
    Brinck, U
    ANTICANCER RESEARCH, 2002, 22 (1A) : 193 - 196
  • [8] Dimerization, translocation and localization of Ku70 and Ku80 proteins
    Koike, M
    JOURNAL OF RADIATION RESEARCH, 2002, 43 (03) : 223 - 236
  • [9] Differential Roles of Ku70 and Ku80 in the MMEJ Phenotype
    Brideau, C. M.
    Jevons, S.
    Groselj, B.
    Bentley, J.
    Kiltie, A. E.
    EUROPEAN JOURNAL OF CANCER, 2012, 48 : S68 - S68
  • [10] Defining the minimal domain of Ku80 for interaction with Ku70
    Osipovich, O
    Durum, SK
    Muegge, K
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (43) : 27259 - 27265
12345