Synthesis and Antitubercular Activity of Novel 1,3,4-Oxadiazole and 1,3,4-Thiadiazole Derivatives

被引：0

作者：

Joshi, Shrinivas D. ^{[1
]}

Tiwari, Sahilkumar ^{[1
]}

Kulkarni, Venkatarao H. ^{[1
]}

机构：

[1] Soniya Educ Trusts, Coll Pharm, Dept Pharmaceut Chem, Novel Drug Design & Discovery Lab, Dharwad, Karnataka, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 27卷 / 04期

关键词：

Oxadiazoles; Thiadiazoles; 2-(1H-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate; N'; N'-Diisopropylethylamine; N'-Dimethyl formamide; Mycobacterium tuberculosis H(37)Rv; Antitubercular activity; ACID HYDRAZIDE ANALOGS; PYRROLE RING-SYSTEMS; ANTIMYCOBACTERIAL AGENTS; POTENTIAL ANTIBACTERIAL; INHIBITORS; OXADIAZOLE; TRIAZOLE;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxadiazole pyrrolyl benzamide derivatives (4a-e) and thiadiazole pyrrolyl benzamide derivatives (5a-e) were synthesized by the reaction of 4-(1H-pyrrol-1-yl) benzoic acid with N-(5-(4substituted phenyl)-1,3,4-oxadiazole-2-amines and N-(5-(4-substituted phenyl)-1,3,4-thiadiazole-2-amines, respectively, in N', N'-dimethyl formamide using 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate as amide coupling agent and N', N'-Diisopropylethylamine as a catalyst. All the newly synthesized compounds (4a-e/5a-e) were screened for in vitro antitubercular activity against Mycobacterium tuberculosis H(37)Rv, and compounds 4c, 4d, 5c, and 5d have exhibited significant minimum inhibitory concentration values.

引用

页码：417 / 421

页数：5

共 50 条

[21] Design, synthesis, and antitubercular activity of some 1,3,4-oxadiazole derivatives.
Parekh, HH
Doshi, RK
Parikh, K
[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 219 : U30 - U30
[22] SYNTHESIS AND ANTIOXIDANT ACTIVITY OF NOVEL 1,3,4-OXADIAZOLE DERIVATIVES
Kumar, Hemanth
Kumar, M. Vijay
Revanasiddappa, B. C.
[J]. HETEROCYCLIC LETTERS, 2019, 9 (03): : 321 - 325
[23] 1,3,4-Oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole derivatives as potential antibacterial agents
Othman, Adil A.
Kihel, Mebrouk
Amara, Sarah
[J]. ARABIAN JOURNAL OF CHEMISTRY, 2019, 12 (07) : 1660 - 1675
[24] Synthesis and multi-spectroscopic DNA binding study of 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives of fatty acid
Hassan, Mohammad F.
Rauf, Abdul
[J]. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2016, 153 : 510 - 516
[25] Synthesis and antimicrobial activity of new 1,2,4-triazole, 1,3,4-oxadiazole, 1,3,4-thiadiazole, thiopyrane, thiazolidinone, and azepine derivatives
Abu-Hashem, Ameen Ali
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 2021, 58 (01) : 74 - 92
[26] Synthesis and evaluation of some novel substituted 1,3,4-oxadiazole and pyrazole derivatives for antitubercular activity
Pattan, Shashikant R.
Rabara, P. A.
Pattan, Jayashri S.
Bukitagar, A. A.
Wakale, V. S.
Musmade, D. S.
[J]. INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2009, 48 (10): : 1453 - 1456
[27] SYNTHESIS OF 1,3,4-THIADIAZOLE DERIVATIVES
TSCHIERSKE, C
GIRDZIUNAITE, D
[J]. JOURNAL FUR PRAKTISCHE CHEMIE, 1991, 333 (01): : 135 - 137
[28] 1,3,4-Oxadiazole and 1,3,4-Thiadiazole Nortopsentin Derivatives against Pancreatic Ductal Adenocarcinoma: Synthesis, Cytotoxic Activity, and Inhibition of CDK1
Carbone, Daniela
Pecoraro, Camilla
Panzeca, Giovanna
Xu, Geng
Roeten, Margot S. F.
Cascioferro, Stella
Giovannetti, Elisa
Diana, Patrizia
Parrino, Barbara
[J]. MARINE DRUGS, 2023, 21 (07)
[29] STUDIES ON SYNTHESIS OF 1,3,4-THIADIAZOLE DERIVATIVES .1. ON SYNTHESIS OF PYRIDYL-1,3,4-THIADIAZOLE DERIVATIVES
KUBOTA, S
OKITSU, T
KOIDA, Y
[J]. YAKUGAKU ZASSHI, 1970, 90 (07): : 841 - &
[30] Synthesis of novel glycosyl 1,3,4-thiadiazole derivatives
Cheng, Feng-Chang
Yin, Long
Liu, Xiu-Jian
Liu, Wei-Wei
Cao, Zhi-Ling
Shi, Da-Hua
Wang, Lei
[J]. JOURNAL OF CHEMICAL RESEARCH, 2016, (10) : 614 - 619

← 1 2 3 4 5 →