Intravenous Immunoglobulins: Evolution of Commercial IVIG Preparations

被引：60
|
作者：
Hooper, John A. [1 ]
机构：
[1] BioCatalyst Res LLC, Liberty, MO 64068 USA
来源：
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2008年 / 28卷 / 04期
关键词：
Intravenous immunoglobulin; Primary immunodeficiency; Manufacture; Commercial;
D O I：
10.1016/j.iac.2008.06.002
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Since its first use in 1952, human immunoglobulin has been used to treat people who have inherited antibody deficiencies. This article summarizes IVIG clinical development in primary immunodeficient patients and manufacturing improvements introduced over time. Manufacturing improvements include purification procedures that have reduced the incidence of adverse events and improved clinical efficacy, as well as virus inactivation and removal steps that have increased safety from blood-borne infections. Current manufacturing procedures, IVIG production trends, and recent clinical trial results are also reviewed.
引用
收藏
页码：765 / 778
页数：14
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