Screening and Structures Characterization of Human Serum Albumin Ligands from Radix Aconiti Alkaloids Extract by Ultrafiltration LC-MSn

被引：5
|
作者：
Zhu Hong-Bin [1 ,2 ]
Liu Shu [1 ]
Wang Chun-Yan [1 ,2 ]
Liu Zhi-Qiang [1 ]
Song Feng-Rui [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, Changchun Ctr Mass Spectrometry, Changchun 130022, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2013年 / 34卷 / 07期
关键词：
Radix aconiti; Ultrafiltration LC-MS; Human serum albumin; NEURAMINIDASE INHIBITORS; MASS; FLAVONOIDS; DNA;
D O I：
10.7503/cjcu20120962
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A ultrafiltration LC-MS screening assay was developed for the screening and structures characterization of human serum albumin(HSA) ligands from the alkaloids extract of Radix aconiti. As a result, 9 compounds that can bind to HSA were found and were identified as 14-benzoylmesaconine, 14-benzoylaconine, 10-OH-mesaconitine, mesaconitine, 10-OH-aconitine, aconitine, hypaconitine, deoxyaconitine and 3,13-deoxyaconitine by ESI-MSn data.
引用
收藏
页码：1635 / 1639
页数：5
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