Recognition of Flavonoids Towards to DNA G-quadruplexes and Duplexes by ESI-MS

被引：2

作者：

Liu Zhen-Shuang ^{[1
]}

Gao Shang ^{[1
]}

Zhao Wai-Ou ^{[2
]}

Qin Yu-Jiao ^{[1
]}

Wang Bing ^{[1
]}

Guo Xin-Hua ^{[1
]}

机构：

[1] Jilin Univ, Coll Chem, Changchun 130012, Peoples R China

[2] Jilin Univ, Hosp 1, Dept Cardiol, Changchun 130021, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2012年 / 33卷 / 08期

关键词：

Electrospray ionization mass spectrometry( ESI-MS ); G-quadruplex DNA; Noncovalent interaction; Flavonoid; IONIZATION MASS-SPECTROMETRY; NUCLEIC-ACIDS; LIGANDS; K+;

D O I：

10.3969/j.issn.0251-0790.2012.08.009

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Electrospray ionization mass spectrometry(ESI-MS) was used for the investigation of noncovalent interactions between flavonoids, including rutin, quercetin, naringin, puerarin, and two types of DNA quadruplexes as well as three kinds of DNA duplexes. Percentage bound of each compound towards to different DNA strands were calculated based on the ion abundances of each DNA strand and DNA-ligand complexes obtained in the mass spectra. The results show that rutin and quercetin selectively bound to the G-quadruplexes, meanwhile, they also show strong binding to the duplexes. In contrast, naringin and puerarin show less selectivity towards to the G-quadrulexes.

引用

页码：1681 / 1685

页数：5

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