Sulfasalazine-induced DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms)

被引：18

作者：

Rudge de Aquino, Renato Telles ^{[1
]}

Vieitas Vergueiro, Carmen Silvia ^{[1
]}

Ruffolo Magliari, Maria Elisa ^{[1
]}

Proenca de Freilas, Thais Helena ^{[1
]}

机构：

[1] Fac Ciencias Med Santa Casa Sao Paulo, Dept Internal Med, Sao Paulo, Brazil

来源：

SAO PAULO MEDICAL JOURNAL | 2008年 / 126卷 / 04期

关键词：

Drug eruptions; Sulfasalazine; Hypersensitivity; Eosinophilia; Sulfonamides;

D O I：

10.1590/S1516-31802008000400006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

CONTEXT: DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a type of drug reaction commonly mistaken for a viral infection. It must be recognized promptly due to its high morbidity and 10% mortality rate. Few cases of DRESS syndrome induced by sulfasalazine have been reported in the literature. CASE REPORT The case of a 47-year-old white Brazilian woman who developed DRESS syndrome eight weeks after starting a course of sulfasalazine for treatment of seronegative arthritis is reported. She presented a skin rash, fever, hepatitis, lymphadenopathy, eosinophilia and atypical lymphocytes. The causative drug was discontinued immediately, but she only improved after treatment with prednisone.

引用

页码：225 / 226

页数：2

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